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Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.
Brain Struct Funct
January 2025
Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond Street, North London, ON, N6A 5C1, Canada.
The dual task cost of gait (DTC) is an accessible and cost-effective test that can help identify individuals with cognitive decline and dementia. However, its neural substrate has not been widely described. This study aims to investigate the neural substrate of the high DTC in older adults across the spectrum of cognitive decline.
View Article and Find Full Text PDFPhytochemical profile and in vitro evaluation of cassava (Manihot esculenta Crantz) foliage as ruminant feed with/without green banana flour.
Sci Rep
January 2025
Animal Production Department, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.
Cassava (Manihot esculenta Crantz) is a crucial crop in tropics and subtropics, primarily cultivated for its tuber. However, its foliage is rich in protein and can supply essential elements for ruminants. The objective of this study was to evaluate the phytochemical compounds by Gas chromatography-MS (GC-MS) and the main phenolic by High Pressure Liquid Chromatography (HPLC) present in cassava foliage, along with the fermentation pattern using a semi-automated gas production (GP) system.
View Article and Find Full Text PDFEffects of cold-pressed wheat germ oil and Bacillus subtilis on growth performance, digestibility, immune status, intestinal microbial enumeration, and gene expression of broilers under heat stress.
Poult Sci
December 2024
Department of Biochemistry, College of Sciences, King Saud University, Riyadh, Saudi Arabia.
This study evaluated the effect of wheat germ oil (WGO), Bacillus subtilis, and their combination on growth performance, immune response, nutrient digestibility, intestinal microbial, oxidative status, and gene expression in heat-stressed broilers. Four hundred one-day-old male Ross 308 broilers were distributed into five pens (20 birds/pen) in four experimental groups: a control (CON) without additives, WGO group fed diet with WGO at 200 mg.kg, BS group fed diet with B.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, San Francisco, Weill Institute for Neurosciences, San Francisco, CA, USA.
Background: Alzheimer's disease (AD) and other dementia risk may be influenced by the immune function and associated with several white blood cell type counts. In cognitively normal Black, Hispanic, and non-Hispanic white older adults we related three white blood cell types previously associated with AD risk to tau positron emission tomography (PET) values in the medial temporal lobe (MTL), where tau accumulates early. We assessed whether amyloid positivity moderated this relationship.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Kansas Medical Center, Kansas City, KS, USA.
Background: Understanding the proteomes of specific cell types within the brain is crucial for elucidating the mechanisms underlying Alzheimer's disease (AD). However, the isolation and analysis of these diverse and low-abundance cell populations remain significant challenges. This study aims to assess GeoMxTM Digital Spatial Profiler (DSP) by NanoString Technologies (NanoString, Seattle, USA) capable of spatially resolving protein expression profile of AD brains extracted from formalin-fixed paraffin-embedded (FFPE) specimens.
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