[Effect of tissue-specific proliferation inhibitors on the level of mitotic activity and cell adhesion in disordered innervation].

In the work there was studied the influence of hepatic chalones on the level of mitotic activity and on the degree of adhesion of hepatocytes after the violation of parasympathetic and sympathetic innervation under the physiological conditions of liver function and in regenerating organ. Some definite regularities were revealed in the change of the power of linkage among the cells of liver parenchyma after the disturbance of its innervation and chalones affected. Significant differences in the effect of the influence of tissue inhibitors of proliferation on the process of regeneration in liver, which has intact or disturbed innervation were discovered. Particularly one can underline the effect of the loss of hepatocytes sensitivity to chalones in vagotomized liver.