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[Reflex sympathetic dystrophy: still a poorly defined entity].

Rev Prat

January 2004

Service d'immuno-rhumatologie, Hôpital qénéral, et Inserm ERIT-M 0207, BP 1519, 21033 Dijon.

The reflex sympathetic dystrophy (algodystrophy) constitutes a large nosological field of which the main characteristics are the appearance of algic and vasomotor symptoms at a segmental level of a limb, in consequence to diverse pathologies (trauma, cardiovascular disease, etc.). The widely accepted theory of a dysregulation of the sympathetic nervous system is nowadays counter-balanced by recent work highlighting the preponderant role of polymodal afferent nerves in the pathophysiology of this disease.

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No tolerance to the antinociceptive action of calcitonin in rats and mice.

Neurosci Lett

April 2004

Département de Biologie, Faculté des Sciences Semlalia BP: 2390, 40 000 Marrakech, Morocco.

The involvement of a central opioid mechanism in the antinociceptive effect of calcitonin is still a matter of controversy. Since a major characteristic of the effects of opioids is tolerance to repeated treatments, we investigated the effects of acute and chronic (over 7 days) calcitonin injections on pain sensitivity in rats and mice. We examine the effect of single and repeated intraventricular (0.

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Antalgic treatment of pain associated with bone metastases.

Crit Rev Oncol Hematol

January 2001

Institute of Anesthesiology and Intensive Therapy, University of Rome La Sapienza, Via Alessandro VII, 40-00167 Rome, Italy.

Pain from metastases of primitive cancer is the first symptom of disease in 15--20% of patients and remains the most common cause of cancer-related pain. 30--70% of patients have metastases at diagnosis, and 80% of them at the moment of death. Functional impairment of skeleton, neurologic symptoms, pathological fractures and pain are the most important indications for palliative treatment which should result in tumor regression, relief in cancer-related symptoms and maintainance of functional integrity.

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The back pain syndrome which accompanies involutional osteoporosis presents a marked heterogeneity. Acute pain may be due to vertebral fractures, whereas chronic pain may eventually accompany established osteoporosis in which clinical and instrumental evidence are present. Back pain is the consequence of the mechanical (internal or external pressure) or chemical stimulation of pain receptors present in bone tissue, along the vessels, in cartilage, joints, disk, ligaments, and also in soft tissue and muscle (with secondary antalgic contracture).

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