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Study on the formation mechanism and effective manipulation of polymorphs and solvates in Osimertinib-Caffeic acid multi-component crystal with distinct properties.
Int J Pharm
December 2024
Guangdong Provincial Key Lab of Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:
Investigating the formation mechanism and effective manipulation of multi-component crystal polymorphs is crucial for facilitating industrial drug development. Herein, five novel Osimertinib-caffeic acid forms were first strategically tailored by varying solvent selection. Theoretical analysis demonstrated this polymorphism is correlated with multiple hydrogen bond donors-acceptors within multi-component system, which provides manipulation space for reconfiguration of intermolecular interactions and structural competition, while solvent further induced or involved in hydrogen-bonded rearrangements.
View Article and Find Full Text PDFComprehensive evaluation of sodium dichloroisocyanurate (NaDCC) tablets as a novel solid-state alternative to conventional membrane cleaning agents in gravity-driven filtration systems.
Chemosphere
December 2024
Department of Environmental Research, Korea Institute of Civil Engineering and Building Technology, Gorang-Daero 283, Ilsanseo-Gu, Goyang, Gyeonggi 10223, Republic of Korea; Department of Civil and Environment Engineering, University of Science and Technology (UST), 217 Gajeong-Ro, Yuseong-Gu, Daejeon, 34113, Republic of Korea. Electronic address:
Gravity-driven membrane (GDM) systems are increasingly recognized as sustainable and energy-efficient solutions for decentralized water treatment. However, membrane fouling, particularly by organic matter, remains a significant operational challenge, necessitating regular chemical cleaning to maintain performance. The present study was undertaken to investigate the cleaning efficiency of sodium dichloroisocyanurate (NaDCC) tablets, a novel solid-state alternative to conventional liquid cleaning agents such as sodium hypochlorite (NaOCl), sodium lauryl sulfate (SLS), acetic acid, and citric acid.
View Article and Find Full Text PDFElectronic and paper delivery of parent proxy and children's report of two scar-specific patient-reported outcome measures (Brisbane Burn Scar Impact Profile and Patient and Observer Scar Assessment Scale): An equivalence study.
Burns
December 2024
Children's Health Research Centre, The University of Queensland, Faculty of Medicine, Herston, Queensland, Australia; Australian Centre for Health Services Innovation (AusHI), Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Introduction: The Brisbane Burn Scar Impact Profile (BBSIP) and the Patient and Observer Scar Assessment Scale (POSAS) are used in burn scar assessment to quantify patient health-related quality of life (HR-QoL). These questionnaires were developed using pen-and-paper delivery methods; however, there is a push towards electronic delivery of these questionnaires in both clinical practice and research. Equivalence testing is required to ensure that validity of these paper questionnaires is maintained electronically.
View Article and Find Full Text PDFA complementary and integrated strategy for multicomponent characterization and attribution of Danning tablet based on convergence and liquid chromatography combined with mass spectrometry.
J Pharm Biomed Anal
December 2024
Shanghai Key Laboratory of Compound Chinese Medicine, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address:
Danning tablet (DNT) is a traditional Chinese medicine (TCM) that contains seven herbal ingredients. It has been clinically used to treat liver and gallbladder diseases in humans. However, the complex composition of TCM prescriptions makes it challenging to fully analyze different polar range compounds.
View Article and Find Full Text PDFAdvanced Wearable Devices for Monitoring Sweat Biochemical Markers in Athletic Performance: A Comprehensive Review.
Biosensors (Basel)
November 2024
Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Wearable technology has advanced significantly, offering real-time monitoring of athletes' physiological parameters and optimizing training and recovery strategies. Recent developments focus on biosensor devices capable of monitoring biochemical parameters in addition to physiological ones. These devices employ noninvasive methods such as sweat analysis, which reveals critical biomarkers like glucose, lactate, electrolytes, pH, and cortisol.
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