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New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs.
Front Chem
December 2024
Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, Tamil Nadu, India.
Ebola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective therapeutics that cover all filoviruses, including both Ebola and Marburg viruses. Therefore, some anti-filovirus drugs such as Pinocembrin, Favipiravir, Remdesivir and others are used to manage infections.
View Article and Find Full Text PDFEbola disease: bridging scientific discoveries and clinical application.
Lancet Infect Dis
December 2024
Pandemic Sciences Institute, Oxford, UK.
The west Africa Ebola disease epidemic (2014-16) marked a historic change of course for patient care during emerging infectious disease outbreaks. The epidemic response was a failure in many ways-a slow, cumbersome, and disjointed effort by a global architecture that was not fit for purpose for a rapidly spreading outbreak. In the most affected countries, health-care workers and other responders felt helpless-dealing with an overwhelming number of patients but with few, if any, tools at their disposal to provide high-quality care.
View Article and Find Full Text PDFInfluence of trust on the acceptance of the RTS,S malaria vaccine in the Kassena-Nankana districts of Ghana.
Malar J
November 2024
School of Public Health, University of Ghana, P. O. Box 65 LG, Legon, Ghana.
Article Synopsis
- * A study in the Kassena Nankana Districts involved 390 mothers and caregivers of young children, where questionnaires and interviews measured trust and knowledge of the RTS,S malaria vaccine, using software for data analysis.
- * Results showed that nearly all mothers (95.4%) were knowledgeable about the malaria vaccine, and 91.4% trusted it; factors affecting vaccine acceptance included education, ethnicity, and information sources.
[Disease Caused by Filoviruses: An Update].
Acta Med Port
January 2025
Faculdade de Medicina. Universidade de Lisboa. Lisboa; Unidade Local de Saúde da Arrábida. Setúbal. Portugal.
The Marburg and Ebola viruses belong to the Filoviridae family and are known to cause emerging zoonotic diseases. These viruses have a high case fatality rate and are easily transmissible from person to person, which makes them capable of triggering outbreaks, including in non-endemic regions, and are also considered agents of bioterrorism. Fruit bats are the natural reservoirs of these filoviruses.
View Article and Find Full Text PDFBarriers and facilitators to healthcare facility utilization by non-Ebola patients during the 2018-2020 Ebola outbreak in the Democratic Republic of Congo.
Glob Health Res Policy
November 2024
Kinshasa School of Public Health, Université de Kinshasa, Kinshasa, Democratic Republic of Congo.
Article Synopsis
- - The study focuses on the barriers and facilitators to accessing healthcare facilities during an Ebola outbreak in North Kivu, highlighting how insecurity and misinformation impacted non-Ebola patients' care.
- - Qualitative interviews with families of deceased patients and healthcare workers revealed that fear, mistrust, and perceptions about the Ebola crisis significantly influenced healthcare decisions, leading many to seek informal care options.
- - Despite challenges like funding shortages and delays in care, community engagement and introducing a free care policy helped increase healthcare facility visits, emphasizing the importance of trust and support in future health crises.
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