Metamaterials are artificial composites that exhibit exotic electromagnetic properties, as the ability of metamaterial slabs to behave like lenses with sub-wavelength resolution for the electric or the magnetic field. In previous works, the authors investigated magnetic resonance imaging (MRI) applications of metamaterial slabs that behave like lenses for the radiofrequency magnetic field. In particular, the authors investigated the ability of MRI metamaterial lenses to increase the signal-to-noise ratio (SNR) of surface coils, and to localize the field of view (FOV) of the coils, which is of interest for parallel MRI (pMRI) applications. A metamaterial lens placed between a surface coil and the tissue enhances the sensitivity of the coil. Although the metamaterial lens introduces losses which add to the losses of the tissue, the enhancement of the sensitivity can compensate these additional losses and the SNR of the coil is increased. In a previous work, an optimization procedure was followed to find a metamaterial structure with minimum losses that will maximize the SNR. This structure was termed magnetoinductive (MI) lens by the authors. The properties of surface coils in the presence of MI lenses were investigated in previous works at the proton frequency of 1.5 T systems. The different frequency dependence of the losses in both the MI lenses and the tissue encouraged us to investigate the performance of MI lenses at different frequencies. Thus, in the present work, the SNR and the pMRI ability of MI lenses are investigated as a function of field strength. A numerical analysis is carried out with an algorithm developed by the authors to predict the SNR behavior of a surface coil loaded with a MI lens at the proton frequencies of 0.5 T, 1.5 T and 3 T systems. The results show that, at 0.5 T, there is a gain in the SNR for short distances, but the SNR is highly degraded at deeper distances. However, at 1.5 T and 3T, the MI lenses provide a gain in the SNR up to a certain penetration depth, which is deeper at 3T, and do not degrade the SNR at deeper distances. These numerical results are checked by means of an experiment. Moreover, a second experiment developed with two-channel arrays of surface coils loaded with MI lenses shows that the pMRI ability of the lenses also improves from 1.5 T to 3 T. This improvement was quantified by means of the calculation of the GRAPPA g-factor.
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Cureus
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Department of Neurological Surgery, Ryofukai Satoh Neurosurgical Hospital, Fukuyama, Hiroshima, JPN.
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January 2025
Graduate School of Environmental Symbiotic System Major, Nippon Institute of Technology 4-1 Gakuendai, Miyashiro Saitama 345-8501 Japan.
Coiled-coil protein carrier (CCPC) 140 is a rigid and anisotropically structured cationic coiled-coil artificial protein that has displayed up to a 1000 times higher level of cellular internalization activity than that of unstructured cell-penetrating peptides. Previous studies have demonstrated that CCPC 140's rigid and anisotropic structural properties and cationic surface properties are important for its superior cellular internalization activity. In this study, we investigated whether each physicochemical characteristic of CCPC 140 effectively contributed to activating the cellular internalization pathway.
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January 2025
Textile and Clothing College, Qingdao University, Qingdao 266071, China.
Fiber-based strain sensors, as wearable integrated devices, have shown substantial promise in health monitoring. However, current sensors suffer from limited tunability in sensing performance, constraining their adaptability to diverse human motions. Drawing inspiration from the structure of the spiranthes sinensis, this study introduces a unique textile wrapping technique to coil flexible silver (Ag) yarn around the surface of multifilament elastic polyurethane (PU), thereby constructing a helical structure fiber-based strain sensor.
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Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, 8092 Zürich, Switzerland.
Proteases, an important class of enzymes that cleave proteins and peptides, carry a wealth of potentially useful information. Devices to enable routine and cost effective measurement of their activity could find frequent use in clinical settings for medical diagnostics, as well as some industrial contexts such as detecting on-line biological contamination. In particular, devices that make use of readouts involving magnetic particles may offer distinct advantages for continuous sensing because material they release can be magnetically captured downstream and their readout is insensitive to optical properties of the sample.
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Yunnan Provincial Key Laboratory for Conservation and Utilization of In-forest Resource, the Key Laboratory of Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of Education, Southwest Forestry University, Kunming 650224, China Southwest Forestry University Kunming China.
Three new fungal species, , and , are proposed based on a combination of the morphological features and molecular evidence. The taxon is characterized by the coriaceous basidiomata with a cream surface, cylindrical basidia, straight, 4-celled, subglobose or ovoid probasidia and thin-walled, narrowly cylindrical basidiospores with septa, measuring as 7-9 × 3.5-4.
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