AI Article Synopsis
- Evidence suggests that beta-retroviruses may be linked to human breast cancer, particularly an exogenous virus similar to mouse mammary tumor virus.
- The article discusses recent findings that support this association, including the role of the endogenous human beta-retrovirus HERV-K.
- It also explores how these viruses might interact with the APOBEC3 family of proteins, indicating a potential mechanism for their involvement in cancer.
Article Abstract
Evidence is accumulating that one or more beta-retrovirus is associated with human breast cancer. Retroviruses can exist as an infectious (exogenous) virus or as a part of the genetic information of cells due to germline integration (endogenous). An exogenous virus with a genome that is highly homologous to mouse mammary tumour virus is gaining acceptance as possibly being associated with human breast cancer, and recently furnished evidence is discussed in this article, as is the evidence for involvement of an endogenous human beta-retrovirus, HERV-K. Modes of interaction are also reviewed and linkages to the APOBEC3 family are suggested.
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| http://dx.doi.org/10.1099/vir.0.070631-0 | DOI Listing |
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