The ever increasing practice of transplantation requires the creation of units specialized in the reception of potential organ donors. The functioning of the organ procurement centre at Bordeaux is described, and the results of 100 procurements performed over a 27-month period are reported. The technical support (electroencephalography, laboratories, etc.) ensures that the donors are under permanent care. Recipients chosen in priority are "super-emergencies" and local patients. One half of the 100 donors came from the Gironde department and the others from 6 neighbouring departments. Procurement takes place 6 hours on average after the 2nd inactive electroencephalogram, and it is multiple in 87 per cent of the cases. Two hundred and fifty-two organs were obtained, including 166 kidneys (8 of which were not utilized), 50 hearts and 36 livers; 55 per cent remained in Bordeaux and 45 per cent were sent to other parts of France or abroad. The cerebral death reception centre must be self-sufficient, independent and permanently accessible. Ideally, local co-ordination is ensured by a physician. Procurements in peripheral hospital are possible but difficult to organize. A greater sensitization, a better regional collaboration and a widening of the criteria used in the selection of donors should result in a further increase in the number of multiple organ procurements.
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Liver Int
February 2025
Department of Hepatobiliary and Digestive Surgery, University Hospital, Rennes 1 University, Rennes, France.
The discrepancy between donor organ availability and demand leads to a significant waiting-list dropout rate and mortality. Although quantitative tools such as the Donor Risk Index (DRI) help assess organ suitability, many potentially viable organs are still discarded due to the lack of universally accepted markers to predict post-transplant outcomes. Normothermic machine perfusion (NMP) offers a platform to assess viability before transplantation.
View Article and Find Full Text PDFCurr Hypertens Rev
January 2025
Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Background: Chronic Kidney Disease (CKD) is a known risk factor for End-Stage Renal Disease (ESRD) and Cardiovascular Diseases (CVD). Renal Doppler Ultrasound (RDU) can detect early renal involvement in CKD using the Renal Resistive Index (RRI).
Aims: This study aimed to investigate the effects of risk factors and clinical complications associated with CKD on RRI among patients with different stages of CKD.
Nephrol Nurs J
January 2025
Kidney Transplant Coordinator, Atrium Health, Carolinas Medical Center in Charlotte, NC.
Patients in need of a kidney transplant have the option of receiving a kidney from a living donor or a deceased donor. Patients in the United States who do not have an available living donor typically wait on the deceased donor waiting list for an average of three to five years, although some patients may wait longer. The waiting list is very complex and intended to allocate kidneys in a fair and equitable manner.
View Article and Find Full Text PDFJ Heart Lung Transplant
February 2025
Department of Cardiothoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Background: Ex-vivo lung perfusion (EVLP) has potential to expand donor lung utilization, evaluate allograft viability, and mitigate ischemia-reperfusion injury. However, trends in EVLP use and recipient outcomes are unknown on a national scale. We examined trends in EVLP use and recipient outcomes in the United States.
View Article and Find Full Text PDFExp Clin Transplant
December 2024
>From the Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Vall d'Hebron Hospital, Barcelona, Spain.
Marginal liver grafts, such as those from cardiac death donors and donors with steatotic organs, are highly vulnerable to ischemia-reperfusion injury. In addition, ex situ graft alteration, either by reduction or splitting, will prolong the static cold storage time and amplify the ischemia-reperfusion injury. Hypothermic oxygenated machine perfusion has the potential to end the oxygen deprivation during preservation and accordingly improve outcomes in some marginal grafts that have been traditionally discarded.
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