AI Article Synopsis
- Laser-assisted bioprinting is an advanced, no-contact technique for cell printing that ensures high resolution and cell viability.
- The study focuses on optimizing printing conditions to reduce shear stress and cell impact during the printing process.
- Key findings include the relationship between the vertex angle of the printing setup and the ability to print mesenchymal stem cells effectively while maintaining stability of the jets under varying laser pulse energies.
Article Abstract
Laser-assisted bioprinting is a versatile, non-contact, nozzle-free printing technique which has demonstrated high potential for cell printing with high resolution. Improving cell viability requires determining printing conditions which minimize shear stress for cells within the jet and cell impact at droplet landing. In this context, this study deals with laser-induced jet dynamics to determine conditions from which jets arise with minimum kinetic energies. The transition from a sub-threshold regime to jetting regime has been associated with a geometrical parameter (vertex angle) which can be harnessed to print mesenchymal stem cells with high viability using slow jet conditions. Finally, hydrodynamic jet stability is also studied for higher laser pulse energies which give rise to supersonic but turbulent jets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1088/1758-5082/6/4/045001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Experimental and numerical research on jet dynamics of cavitation bubble near dual particles.
Ultrason Sonochem
November 2024
School of Energy Power and Mechanical Engineering, North China Electric Power University, Beijing 102206, China. Electronic address:
The current paper delves into the jet dynamics arising from a cavitation bubble in proximity to a dual-particle system, employing both experimental methodology and numerical simulation. The morphological development of a laser-induced bubble as well as the production of jets are captured by utilizing high-speed photography. The principles of bubble morphology evolution and jet formation are revealed by a OpenFOAM solver, which takes into account the effects of two-phase fluid compressibility, phase changes, heat transfer, and surface tension.
View Article and Find Full Text PDFThe perspective of ceRNA regulation of circadian rhythm on choroidal neovascularization.
Sci Rep
November 2024
Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Abnormal growth of blood vessels (choroidal neovascularization) can lead to age-related macular degeneration (AMD) and eventually cause vision loss due to detachment of the retinal pigmented epithelium. This indicates that choroidal neovascularization is important for the treatment of AMD. The circadian clock in the mammalian retina is responsible for controlling various functions of the retina, enabling it to adjust to changes in light and darkness.
View Article and Find Full Text PDFNeedle-Free Targeted Injections Using Bubble Laser Technology in Therapeutics.
Langmuir
November 2024
UKM─Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia UKM, Bangi 43600, Malaysia.
This work explores bubble laser technology as an alternative to needles in injection systems for vaccination, cancer treatment, insulin delivery, and catheter hygiene. The technology leverages laser-induced microfiltration and bubble dynamics to create high-speed pneumatic jets that penetrate the skin without needles, addressing discomfort, infection risk, and needle-related concerns. The system's performance is analyzed based on laser wavelength, pulse duration, and Gaussian beam droplet size.
View Article and Find Full Text PDFLaser Spectroscopic Characterization of Supersonic Jet-Cooled 2,6-Diazaindole (26DAI).
J Phys Chem A
October 2024
Department of Chemistry, IIT Hyderabad, Sangareddy 502284, Telangana, India.
The article presents a comprehensive laser spectroscopic characterization of a nitrogen-rich indole derivative, namely, 2,6-diazaindole (26DAI), in the gas phase. A supersonic jet-cooled molecular beam of 26DAI was characterized using two-color resonant two-photon ionization (2C-R2PI) and laser-induced fluorescence spectroscopy (LIF) to investigate the electronic excitation. The S ← S origin transition was obtained at 33915 cm, which was red-shifted from that of one (indole) and two (7-azaindole) nitrogen-containing indole derivatives by 1317 and 713 cm, respectively.
View Article and Find Full Text PDFSpectroscopic characterization of the complexes of 2-(2'-pyridyl)-benzimidazole and (HO), (CHOH), and (NH) isolated in the gas phase.
Phys Chem Chem Phys
October 2024
Center for Interdisciplinary Program, IIT Hyderabad, 502284, India.
The hydrogen-bonded docking preferences of small solvent molecules on 2-(2'-pyridyl)-benzimidazole (PBI) were studied experimentally aided by computational findings. The PBI-S complexes (S = HO, CHOH, and NH) were produced in a supersonically jet-cooled molecular beam and probed using resonant two-photon ionization and laser-induced fluorescence spectroscopy, with multiple isomers confirmed by UV-UV hole-burning spectroscopy. Two distinct isomers of PBI-HO and PBI-(HO) complexes were identified, while PBI-CHOH and PBI-NH each formed a single 1 : 1 and 1 : 2 complex.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!