AI Article Synopsis
- The study investigated the effects of vanadium sulfate (VOSO4) on pancreatic function in both healthy and diabetic rats over a 30-day period, using doses of 5 and 10 mg/kg.
- In diabetic rats treated with VOSO4, blood glucose levels decreased and insulin levels increased, particularly with the higher dosage, indicating restoration of normal glucose metabolism.
- Additionally, VOSO4 treatment led to an increase in insulin-producing beta cells in the pancreatic islets of both nondiabetic and diabetic rats, suggesting potential for beta cell regeneration.
Article Abstract
We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity. VOSO4 also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats. Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium. Therefore, VOSO4 treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and/or regeneration in normal or diabetic rats.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156977 | PMC |
| http://dx.doi.org/10.1155/2014/540242 | DOI Listing |
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