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Sebaceous carcinoma in immunosuppressed patients: a narrative review.
Arch Dermatol Res
January 2025
Department of Dermatology, Columbia University Irving Medical Center, 161 Ft Washington Ave, 12th Floor, New York, NY, 10032, USA.
Sebaceous carcinoma is a rare cutaneous malignancy of sebaceous glands, but it is up to 25-fold more common in immunosuppressed individuals. In this narrative review, we examine the current literature on the pathogenesis, incidence, risk factors, prognosis, treatment, and surveillance of sebaceous carcinoma in immunosuppression and highlight practical considerations for providers who care for these patients. Increased incidence may be related to decreased immune surveillance, susceptibility to an unknown viral trigger, microsatellite instability, immunosuppressive medications, and unmasking of occult Muir-Torre Syndrome.
View Article and Find Full Text PDFOverall drivers of mortality in sebaceous carcinoma patients with and without Muir-Torre syndrome: A population-based analysis.
J Am Acad Dermatol
December 2024
Department of Dermatology, Baylor College of Medicine, Houston, Texas.
Sebaceous gland hyperplasia is a benign cutaneous entity commonly seen in older men. Occasionally, it can develop in young patients on immunosuppression with cyclosporine or in adolescent boys in the peripubertal age group. It is extremely rare in young children with no reports of eyelid involvement.
View Article and Find Full Text PDFA novel lynch syndrome kindred with hereditary adrenal cortical carcinoma.
Cancer Genet
November 2024
Eastern Virginia Medical School, Norfolk, VA, USA; Virginia Oncology Associates, Norfolk, VA, USA.
Article Synopsis
- Adrenal cortical carcinoma (ACC) is a rare and aggressive cancer, often with a poor prognosis, underscoring the necessity for early detection and treatment through surgical resection.
- This case study features a 59-year-old man with a hereditary form of ACC linked to Muir-Torre syndrome, indicating a connection between Lynch syndrome and increased risk of this malignancy, particularly in families with a history of ACC.
- The findings stress the importance of targeted cancer screening for individuals with Lynch syndrome and the critical need for distinct germline and somatic genetic testing in cancer cases to better inform treatment options.
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