Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159904 | PMC |
| http://dx.doi.org/10.4103/0970-9371.138674 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical advancements in mRNA vaccines against viral infections.
Clin Immunol
December 2024
Department of Microbiology, Gachon University College of Medicine, Incheon, Republic of Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Republic of Korea; Korea mRNA Vaccine Initiative, Gachon University, Seongnam, Republic of Korea. Electronic address:
Over the last decade, mRNA vaccines development has shown significant advancement, particularly during the COVID-19 pandemic. This comprehensive review examines the efficacy of pivotal vaccines against emerging COVID-19 variants and strategies for enhancing vaccine effectiveness. It also explores the versatility of mRNA technology in addressing other infectious diseases such as influenza, respiratory syncytial virus, HIV, cytomegalovirus, Ebola, Zika, Rabies, and Nipah viruses.
View Article and Find Full Text PDFGenetic and Clinical-epidemiologic Profile of hRSV in Pediatric Patients in Southern Brazil: A Four-year Hospital Surveillance Study.
Pediatr Infect Dis J
December 2024
Public Health Laboratory, Secretaria de Saúde do Estado do Paraná, Curitiba, Brazil.
Background: Respiratory syncytial virus (hRSV) infections primarily cause acute respiratory illness and pediatric hospitalizations. We examined the hRSV molecular epidemiology in a pediatric cohort over a 4-year period and described the interrelationship with clinical data.
Methods: A cross-sectional study was conducted from 2014 to 2017 on children with acute respiratory illness.
Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins.
mBio
December 2024
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Unlabelled: A novel Hendra virus (HeV) genotype (HeV genotype 2 [HeV-g2]) was recently isolated from a deceased horse, revealing high-sequence conservation and antigenic similarities with the prototypic strain, HeV-g1. As the receptor-binding (G) and fusion (F) glycoproteins of HeV are essential for mediating viral entry, functional characterization of emerging HeV genotypic variants is key to understanding viral entry mechanisms and broader virus-host co-evolution. We first confirmed that HeV-g2 and HeV-g1 glycoproteins share a close phylogenetic relationship, underscoring HeV-g2's relevance to global health.
View Article and Find Full Text PDFImpact of Variants, Epidemiological Trends, and Comorbidities on Hospitalization Rates of Unvaccinated Children in Brazil: A Retrospective Study (2020-2022).
Influenza Other Respir Viruses
December 2024
Infectious Diseases Division, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil.
This retrospective study aimed to investigate the impact of the emergence of new variants and the epidemiological scenario on hospitalization rates of unvaccinated children (0-12 years) in Brazil. The study included 1614 children admitted to a hospital between March 2020 and December 2022 but 101 (6.3%) of them testing positive for COVID-19 via RT-PCR.
View Article and Find Full Text PDFEffects of nonpharmaceutical interventions during COVID-19 pandemic on pediatric asthma exacerbations and viral infections.
J Allergy Clin Immunol Glob
November 2024
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Ark.
Article Synopsis
- NPIs significantly reduced asthma exacerbations and viral infections in pediatric patients during their enforcement from March 2020 to December 2022.
- A total of 5,758 asthma exacerbations were recorded, with a 50% decline during NPIs, while 87% of the 70,682 respiratory tests returned positive for pathogens but showed decreased rates for some viruses.
- After the NPIs ended, asthma exacerbations returned to pre-pandemic levels, and an unexpected spike in respiratory syncytial virus infections highlighted the importance of ongoing monitoring.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!