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Severe neonatal hypotonia due to variant affecting function of ZnT5 zinc transporter.
JIMD Rep
January 2025
The Morris Kahn Laboratory of Human Genetics, Faculty of Health Sciences Ben Gurion University Beer-Sheva Israel.
The tightly-regulated spatial and temporal distribution of zinc ion concentrations within cellular compartments is controlled by two groups of Zn transporters: the 14-member ZIP/SLC39 family, facilitating Zn influx into the cytoplasm from the extracellular space or intracellular organelles; and the 10-member ZnT/SLC30 family, mobilizing Zn in the opposite direction. Genetic aberrations in most zinc transporters cause human syndromes. Notably, previous studies demonstrated osteopenia and male-specific cardiac death in mice lacking the ZnT5/ zinc transporter, and suggested association of two homozygous frameshift variants with perinatal mortality in humans, due to hydrops fetalis and hypertrophic cardiomyopathy.
View Article and Find Full Text PDFSpatiotemporal analysis of mosquito-borne infections and mosquito vectors in mainland Portugal.
BMC Infect Dis
January 2025
EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, nº 135, Porto, 4050 - 600, Portugal.
Background: The incidence of mosquito-borne infections has increased worldwide. Mainland Portugal's characteristics might favour the (re)emergence of mosquito-borne diseases. This study aimed to characterize the spatial distribution of vectors and notification rates of imported cases of mosquito-borne infections in mainland Portugal and demarcate the areas where these geographies overlap.
View Article and Find Full Text PDFStatistical learning of spatiotemporal target regularities in the absence of saliency.
Atten Percept Psychophys
January 2025
Department of Experimental and Applied Psychology, Vrije Universiteit Amsterdam, Van Der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
In previous studies, it was established that individuals can implicitly learn spatiotemporal regularities related to how the distribution of target locations unfolds across the time course of a single trial. However, these regularities were tied to the appearance of salient targets that are known to capture attention in a bottom-up way. The current study investigated whether the saliency of target is necessary for this type of learning to occur.
View Article and Find Full Text PDFThe trophic distribution of biomass in ecosystems with co-occurring wildlife and livestock.
Sci Rep
January 2025
Department of Natural History, NTNU University Museum, Norwegian University of Science and Technology, Trondheim, Norway.
Trophic interactions regulate populations, but anthropogenic processes influence primary productivity and consumption by both herbivore and carnivore species. Trophic ecology studies often focus on natural systems such as protected areas, even though livestock globally comprise the majority of terrestrial vertebrate biomass. Here we explore spatial and temporal patterns in the distribution of biomass between plants, and large herbivores and carnivores (> 10 kg) in Norwegian rangelands, including both wildlife and livestock.
View Article and Find Full Text PDFTigers in their new territory: intraspecific interactions among the reintroduced tiger population in Panna Tiger Reserve, Central India.
Sci Rep
January 2025
Wildlife Institute of India, Dehradun, 248001, Uttarakhand, India.
Intra-specific interactions among top carnivores are among the most intriguing behavioural aspects and essential components of population dynamics. Static interactions pertain to space use, while dynamic interactions involve spatio-temporal patterns influenced by social structure, distribution, mate selection, and density. Previous studies have focused on static interactions, successfully estimating spatial overlap but leading to a knowledge gap of dynamic interaction to be able to compute attraction and avoidance on similar spatio-temporal scales.
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