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Regression of Clinically Diagnosed Ocular Kaposi Sarcoma Post-Initiation of Highly Active Antiretroviral Therapy.
Am J Trop Med Hyg
December 2024
Department of Ophthalmology, Faculty of Medical Sciences, The University of the West Indies, St. Michael, Barbados.
Kaposi sarcoma is a low-grade vascular neoplasm linked to the human herpesvirus 8, with the AIDS-associated epidemic variant being the most common and aggressive. Although Kaposi sarcoma more commonly affects the cutaneous tissues, lymph nodes, and visceral organs, it can also be present in ocular and ocular adnexal tissues. We report a case of a 58-year-old Indo-Caribbean woman living with AIDS who presented with a large upper eyelid mass that was clinically diagnosed as Kaposi sarcoma.
View Article and Find Full Text PDFPrevalence of Kaposi sarcoma in the United States: SEER cross-sectional study.
Proc (Bayl Univ Med Cent)
December 2024
Cullen College of Engineering, University of Houston, Houston, Texas, USA.
Primary Kaposi sarcoma (KS) is a rare cancer caused by human herpesvirus-8 that most often affects people with compromised immune systems. Since knowledge of the relationship between disease and sociodemographic factors contributes to the development of precision medicine, we investigated the prevalence of KS within the US population. Using SEER, we found that the Black population had the highest prevalence rate in 2018 compared to other racial groups.
View Article and Find Full Text PDFIntroduction: Castleman disease (CD) represents a spectrum of heterogeneous lymphoproliferative disorders sharing peculiar histopathological features, clinically subdivided into unicentric CD (UCD) and multicentric CD (MCD) and presenting with variable inflammatory symptoms. Interleukin (IL)-6 and other cytokines play a major role in mediating CD inflammatory manifestations. Although the local microenvironment seems to be among the major sources of hypercytokinemia, the precise cellular origin of IL-6 production in CD is still debated.
View Article and Find Full Text PDFMicroneedle-Array-Mediated Transdermal Delivery of GCV-Functionalized Zeolitic Imidazolate Framework-8 Nanoparticles for KSHV Treatment.
Int J Mol Sci
December 2024
Key Laboratory of Xinjiang Endemic and Ethnic Diseases, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, School of Medicine, Shihezi University, Shihezi 832003, China.
Kaposi's sarcoma-associated herpesvirus (KSHV) is a variety of the human gamma-herpesvirus that often leads to the occurrence of malignant tumors. In addition, the occurrence of Kaposi's sarcoma is a major cause of death among AIDS patients. Ganciclovir (GCV) is the most widely used drug against KSHV infection in the clinic.
View Article and Find Full Text PDFA KSHV-targeted small molecule efficiently blocks SARS-CoV-2 infection via inhibiting expression of EGFR and Cyclin A2.
Emerg Microbes Infect
December 2025
MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Article Synopsis
- The COVID-19 pandemic has resulted in increased cases of co-infection with SARS-CoV-2 and the Kaposi's sarcoma-associated herpesvirus (KSHV), leading to higher mortality rates due to the lack of targeted treatments.
- Cambogin, a natural product, has shown promise in reducing tumors associated with KSHV in mice, but its effects on SARS-CoV-2 were not fully understood until recent research.
- The study reveals that Cambogin targets 46 host genes affected by both viruses and effectively inhibits SARS-CoV-2 replication while also slowing the growth of KSHV-induced tumors, suggesting its potential as a treatment for patients co-infected with both viruses.
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