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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity.
Nat Commun
January 2025
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
The inherent antigen cross-reactivity of the T cell receptor (TCR) is balanced by high specificity. Surprisingly, TCR specificity often manifests in ways not easily interpreted from static structures. Here we show that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen and its wild-type (WT) counterpart emerges from distinct motions within the HLA-A3 peptide binding groove that vary with the identity of the peptide's first primary anchor.
View Article and Find Full Text PDF"Stamp the tunnel"- Innovative tool - for perfection in manual small incision cataract surgery.
Indian J Ophthalmol
September 2024
DNB Resident, Aravind Eye Hospital and PG Institute of Ophthalmology, Tirunelveli, Tamil Nadu, India.
Article Synopsis
- Manual small incision cataract surgery (SICS) is a safe and cost-effective alternative to phacoemulsification, particularly beneficial for patients in developing countries and for complex cases in developed nations.
- The new "Tunnel stamp" device assists novice surgeons in making precise sclero corneal tunnels (SCTs) by guiding incision lengths and shapes, thereby reducing complications.
- Future plans involve designing the device in transparent flexible silicon and in various sizes to cater to different cataract types, improving alignment and overall surgical outcomes.
Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity.
Res Sq
May 2024
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
The inherent cross-reactivity of the T cell receptor (TCR) is balanced by high specificity, which often manifests in confounding ways not easily interpretable from static structures. We show here that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen derived from mutant and its wild-type (WT) counterpart emerges from motions within the HLA binding groove that vary with the identity of the peptide's first primary anchor. The motions form a dynamic gate that in the complex with the WT peptide impedes a large conformational change required for TCR binding.
View Article and Find Full Text PDFMeningioma and Other Meningeal Tumors.
Adv Exp Med Biol
July 2023
Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. Ospedale San Raffaele, Vita-Salute University, Via Olgettina 60, 20132, Milano, Italy.
Meningiomas develop from meningothelial cells and approximately account for more than 30 percent of central nervous system (CNS) tumors. They can occur anywhere in the dura, most often intracranially and at dural reflection sites. Half of the cases are usually at parasagittal/falcine and convexity locations; other common sites are sphenoid ridge, suprasellar, posterior fossa, and olfactory groove.
View Article and Find Full Text PDFReduced Slit Rolling Power in Rebar Steel Production.
Materials (Basel)
March 2023
School of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
The rolling process of rebar steel production is one of the well established manufacturing processes; however, it should be subjected to revision and redesign for productivity enhancement and power reduction throughout the slit rolling process. In this work, slitting passes are extensively reviewed and modified for the attainment of better rolling stability and reduction in power consumption. The study has been applied for grade B400B-R Egyptian rebar steel, which is equivalent to steel grade ASTM A615M, Grade 40.
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