AI Article Synopsis
- The study investigated the effects of transplanting adipose-derived mesenchymal stem cells into the brains of mice with Alzheimer's disease.
- Results showed increased cell growth in specific brain regions, indicating enhanced neurogenesis and the production of neuroblasts.
- The transplantation not only improved neurogenic activity but also reduced oxidative stress and cognitive impairment in the mice, suggesting potential benefits for functional recovery in Alzheimer's disease.
Article Abstract
In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer's disease model mice. Immunofluorescence staining revealed that the number of newly generated (BrdU(+)) cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer's disease mice after adipose-derived mesenchymal stem cell transplantation, and there was also a significant increase in the number of BrdU(+)/DCX(+) neuroblasts in these animals. Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well. Furthermore, adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice. Based on these findings, we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer's disease mice, thereby facilitating functional recovery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146257 | PMC |
| http://dx.doi.org/10.4103/1673-5374.131596 | DOI Listing |
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