AI Article Synopsis
- Several studies indicate that Gastrodia elata Blume, a Chinese herb, can prevent cell death caused by amyloid beta-peptides linked to Alzheimer's disease.
- Researchers created a rat model of Alzheimer's by injecting amyloid beta and then treated the rats with different doses of Gastrodia elata Blume over 52 days.
- The results showed improved spatial memory, reduced amyloid deposits in the brain, and increased levels of choline acetyltransferase, indicating that this herb may offer therapeutic benefits for Alzheimer's disease.
Article Abstract
Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ25-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer's disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume, while Ellman method showed significant decrease in the activity of acetylcholinesterase in all three regions (prefrontal cortex, medial septum and hippocampus). These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer's disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145891 | PMC |
| http://dx.doi.org/10.3969/j.issn.1673-5374.2013.12.001 | DOI Listing |
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