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Development of a Novel Human Serum Albumin-Based Tool for Effective Drug Discovery: The Investigation of Protein Quality and Immobilization.
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Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111Budapest, Hungary.
The binding ability of human serum albumin (HSA) on active pharmaceutical ingredients (APIs) is one of the most important parameters in the early stages of drug discovery. In this study, an immobilized HSA-based tool was developed for the rapid and easy in vitro screening of API binding. The work explored the serious incompleteness in the identification of HSA used for in vitro screening published in the last five years.
View Article and Find Full Text PDFRapid Synthesis of Carbon-Supported Ru-RuO₂ Heterostructures for Efficient Electrochemical Water Splitting.
Adv Sci (Weinh)
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Department of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, California, 95064, USA.
Development of high-performance electrocatalysts for water splitting is crucial for a sustainable hydrogen economy. In this study, rapid heating of ruthenium(III) acetylacetonate by magnetic induction heating (MIH) leads to the one-step production of Ru-RuO₂/C nanocomposites composed of closely integrated Ru and RuO₂ nanoparticles. The formation of Mott-Schottky heterojunctions significantly enhances charge transfer across the Ru-RuO interface leading to remarkable electrocatalytic activities toward both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in 1 m KOH.
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Mikrochim Acta
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College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China.
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