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Preclinical investigation of [Tb]Tb-DOTATATE and [Tb]Tb-DOTA-LM3 for tumor-targeted alpha therapy.
Eur J Nucl Med Mol Imaging
January 2025
Center for Radiopharmaceutical Sciences, PSI Center for Life Sciences, Villigen-PSI, 5232, Switzerland.
Purpose: Terbium-149 is a short-lived α-particle emitter, potentially useful for tumor-targeted therapy. The aim of this study was to investigate terbium-149 in combination with the somatostatin receptor (SSTR) agonist DOTATATE and the SSTR antagonist DOTA-LM3. The radiopeptides were evaluated to compare their therapeutic efficacy in vitro and in vivo.
View Article and Find Full Text PDFDiagnosis of Bone Metastasis due to Medullary Thyroid Cancer With Tc- (V) DMSA SPECT Imaging.
Clin Case Rep
December 2024
Department of Nuclear Medicine, Medical School Tabriz University of Medical Sciences Tabriz Iran.
Given the limited availability of PET/CT scans, Tc-(V) DMSA scintigraphy can be used to investigate possible metastases, especially in bone, in individuals with medullary thyroid cancer, even if there are no noticeable signs or symptoms of pain.
View Article and Find Full Text PDFLong-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis.
Int Braz J Urol
November 2024
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - HCFMUSP, SP, Brasil.
Purpose: This prospective study aimed to identify risk factors associated with progression to stage 3 chronic kidney disease (CKD) and the occurrence of kidney stone formation or growth following nephrectomy for urolithiasis.
Materials And Methods: From January 2006 to May 2013, patients undergoing nephrectomy for urolithiasis were enrolled. Renal function was assessed using estimated glomerular filtration rate (eGFR) via the Chronic Kidney Disease Epidemiology Collaboration equation, while kidney stone events were detected using computed tomography.
Incidental Renal Infarction on imaging for Abdominal Aortic Aneurysm.
J Pak Med Assoc
November 2024
Nuclear Medicine Department, East Kent University Hospitals NHS Foundation Trust, UK.
Article Synopsis
- A 59-year-old man undergoing surveillance for an abdominal aortic aneurysm and peripheral artery disease was evaluated through a CT Angiogram of the aorta.
- The scan revealed a 6.2cm abdominal aortic aneurysm with significant thrombus, occluded arteries, and calcified stenosis in key blood vessels.
- A Tc-99m DMSA renal scan was performed to assess the extent of kidney infarction and to evaluate the functional differences between the kidneys.
Simultaneous segmentation and classification of Tc-DMSA renal scintigraphic images with a deep learning approach.
EJNMMI Rep
October 2024
School of Biomedical Engineering, ShanghaiTech University, Shanghai, China.
Background: Tc-DMSA scan plays an important role in assessing functional abnormalities in kidneys. As a promising network for deep learning (DL), Mask R-CNN has the capability of simultaneously segmenting and classifying objects in images. In this study, we tested the feasibility and accuracy of Mask R-CNN in diagnosing acute pyelonephritis (APN) and segmenting kidneys in Tc-DMSA scintigraphic images.
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