AI Article Synopsis
- Heart failure in congenital heart disease can affect 20% of patients, impacting their growth, neurodevelopment, and overall prognosis.
- Traditional medications like digoxin, diuretics, and ACE-inhibitors lack strong trial support, while beta-blocker propranolol has shown positive effects in treating heart failure in infants.
- The author has treated severe heart failure in infants without serious side effects, using careful diuretic management to prevent negative impacts on cardiac remodeling.
Article Abstract
The prevalence of heart failure in patients with congenital heart disease, mainly due to large left to right shunts, is as high as 20%. Heart failure has a high impact on prognosis, growth and neurodevelopment. Prior to surgery or after palliative procedures children need a medical heart failure therapy. The traditional therapy with digoxin, diuretics and ACE-inhibitors is not supported by prospective randomized trials. Propranolol had a significant beneficial effect on the clinical heart failure score, neurohormonal activation, heart rate variability and cardiac remodeling in the prospective randomized trial CHF-Pro-Infant. Beta-blocker dosages depend on heart rate with a target between 100 and 110 bpm in infants and an average dose of 2mg/kg/day after a titration period of 2 to 3 weeks. Within the last 18 years after the first case the author treated only infants with severe heart failure and highly elevated Pro-BNP-levels (8879 pg/ml on average). However we never observed serious side effects due to worsening heart failure, severe bradycardia or pulmonary obstruction. Diuretics are given as low as necessary to prevent the activation of the renin-angiotensin-aldosterone system with its detrimental effect on cardiac remodeling.
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| http://dx.doi.org/10.2174/1574887109666140908123601 | DOI Listing |
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