AI Article Synopsis
- - Chronic heart failure leads to extended sympathetic stimulation, which worsens heart function.
- - Beta-blockers help mitigate this stimulation by improving heart function, including left ventricular performance and heart rate control.
- - These medications also prevent dangerous heart rhythms and reduce the workload on the heart by lowering cardiac afterload and preload.
Article Abstract
Patients with chronic heart failure have prolonged sympathetic stimulation and subsequent worsening of the failing heart function. Beta-blockers (non-selective, cardio-selective, and non-selective with ancillary properties) counteract the effects of prolonged sympathetic stimulation. Beta-blocker therapy results in the improvement of the left ventricular systolic and diastolic function, reversal remodeling, heart rate control, effective prevention of the malignant arrhythmias, and lowering of the both cardiac afterload and preload in patients with chronic heart failure.
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| http://dx.doi.org/10.2174/1574887109666140908125402 | DOI Listing |
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