Four new polycyclic meroterpenoids from Ganoderma cochlear.

Org Lett

Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.

Published: October 2014

Four pairs of new polycyclic-meroterpenoid enantiomers, ganocins A-C (1-3) possessing a spiro[4,5]decane ring system, along with ganocin D (4) with an eight-membered ring, were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data and X-ray diffraction crystallography. Their anti-AChE activities were evaluated, and a possible biogenetic pathway was also proposed.

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http://dx.doi.org/10.1021/ol5023189DOI Listing

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