Effect of low dose ionising radiation and nitric oxide on the state of animal blood system.

Objective: to investigate the effects of a prolonged influence of nitric oxide and low dose ionizing radiation on the blood system.

Materials And Methods: Adult random-bred male rats 120-150 g of body weight. Animals were treated with different factors: inhalation of nitric oxide for 1 month (14 h per day), fractionated X-ray irradiation (1.0 Gy total absorbed dose), and joint impact of both factors. Hematological, biochemical and biophysical parameters were investigated.

Results: Prolonged action of nitric oxide and low dose ionizing radiation on the state of animal blood system was asayed. The radioprotective effects of nitric oxide on morpho-functional parameters was shown. These effects emerged in the reaction of erythroid hematopoetic pool and lymphocyte series at a level of disorders of oxidative metabolism, decrease of atypical lymphocytes content in peripheral blood.

Conclusion: Nitric oxide within joint prolonged impact with low dose ionizing radiation makes a radioprotective effect on the blood system. Combined effect of these factors is characterized by the influence on different metabolic pathways and results in better adaptation than under their separate impact.