Emerging adults demonstrate the highest rates of deliberate self-harm (DSH) and thus represent a population in need of further study. While child maltreatment (CM) history is a risk factor for DSH, the mechanisms behind this relationship are not fully understood. This study tested a model of mechanisms linking CM with DSH (likelihood of engaging in the behavior and frequency among those who self-harm) via negative urgency (tendency to engage in impulsive behaviors under conditions of negative affect), distress tolerance, sense of control, and desire for control in a sample of college students. As hypothesized, CM had a strong positive direct association with both the likelihood and frequency of DSH. CM was positively associated with negative urgency and inversely associated with distress tolerance and sense of control. Negative urgency was positively associated with DSH likelihood and frequency. Distress tolerance was not directly associated with DSH but was indirectly associated with DSH likelihood and frequency via negative urgency. Sense of control was not associated with the likelihood of engaging in DSH; however, among those who endorsed a history of DSH, sense of control was positively associated with DSH frequency. Desire for control was not associated with either CM or DSH.
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http://dx.doi.org/10.1177/1077559514548315 | DOI Listing |
J Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Brain Spine
December 2024
Departments of Orthopaedic Surgery and Neurological Surgery, Duke University Health System, Durham, NC, USA.
Introduction: The normative relationship between lumbar intervertebral disc space height (DSH) and neuroforaminal dimensions (NFD) has yet to be defined.
Research Question: The purpose of this study was to investigate the relationship between lumbar DSH and NFD using computed tomography (CT), accounting for influences of patient demographic and anthropometric characteristics.
Materials And Methods: We analyzed CT imaging of 350 female and 350 male patients.
Med J Armed Forces India
December 2024
Professor, Medicine (Unit 4), Christian Medical College, Vellore, Tamilnadu, India.
Background: Pyrethroid insecticides are commonly used insecticides. This study was undertaken to characterize the clinical profile and outcome of deliberate self-harm (DSH) with type 1 and type 2 pyrethroids and identify factors associated with need for hospitalization.
Methods: This retrospective study was conducted in a tertiary care hospital in South India to study the clinical features, treatment, and outcome of patients with pyrethroid poisoning due to DSH.
Cureus
November 2024
University Medical Unit, Batticaloa Teaching Hospital, Batticaloa, LKA.
Background: Deliberate self-harm (DSH) by poisoning is a significant public health concern worldwide. This study aimed to analyze the demographic, socioeconomic, and psychological factors contributing to self-harm by poisoning in patients admitted to a tertiary care hospital in Sri Lanka.
Methods: A cross-sectional study was conducted on 101 patients admitted to the hospital for poisoning-related self-harm.
Otol Neurotol
February 2025
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Objective: To report hearing preservation (HP) outcomes based on anticoagulation/antiplatelet use (blood thinner, BT) following cochlear implantation (CI).
Study Design: Retrospective cohort.
Setting: Tertiary referral center.
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