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| http://dx.doi.org/10.1073/pnas.1414387111 | DOI Listing |
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Development of Stabilized and Aqueous Dissolvable Nanosuspension Encompassing BCS Class IV Drug via Optimization of Process and Formulation Variables.
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Raj Kumar Goel Institute of Technology (Pharmacy), 5-Km. Stone, Delhi-Meerut Road, Ghaziabad, Uttar Pradesh, India.
Background: Nanosuspension has emerged as an effective, lucrative, and unequalled approach for efficiently elevating the dissolution and bioavailability of aqueous soluble drugs. Diverse challenges persist within this domain, demanding further comprehensive investigation and exploration.
Objective: This study aims to design, develop, optimise formulation and process variables, and characterise the stabilised aqueous dissolvable nanosuspension using chlorthalidone as a BCS class- IV drug.
Highlighting Free-Recovery and Work-Generating Shape Memory Effects at 80r-PET Thermoformed Cups.
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Faculty of Materials Science and Engineering, "Gheorghe Asachi" Technical University of Iași, Blvd. Dimitrie Mangeron 71A, 700050 Iasi, Romania.
The paper starts by describing the manufacturing process of cups thermoformed from extruded foils of 80% recycled PET (80r-PET), which comprises heating, hot deep drawing and cooling. The 80r-PET foils were heated up to 120 °C, at heating rates of the order of hundreds °C/min, and deep drawn with multiple punchers, having a depth-to-width ratio exceeding 1:1. After puncher-assisted deformation, the cups were air blown away from the punchers, thus being "frozen" in the deformed state.
View Article and Find Full Text PDFThickness Dependent Structural Transition in Ph-BTBT-10 Thin Films and Stabilization of the Ubiquitous Interface Bilayer.
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Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), Campus UAB, Carrer dels Til·lers, s/n, Bellaterra, 08193 Barcelona, Spain.
The influence of the film/substrate interface and the role of film thickness on the structural transition temperature for thin films of the asymmetric BTBT derivative 7-decyl-2-phenyl[1]benzothieno[3,2-][1]-benzothiophene (Ph-BTBT-10) have been addressed by using Kelvin probe force microscopy (KPFM) and synchrotron grazing incidence wide angle X-ray scattering (GIWAXS). Our data strongly suggest that the structural transformation from a single-layer phase to the thermodynamically stable bilayer structure develops from the bottom of the film to its surface. Contrary to observations in other organic semiconductor films, notably, the thinner the Ph-BTBT-10 film, the lower is the transition temperature.
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College of Photonics, National Yang Ming Chiao Tung University, 301 Gaofa 3rd Road, Tainan, 71150, Taiwan.
Nanoscale light sources are demanded vigorously due to rapid development in photonic integrated circuits (PICs). III-V semiconductor nanowire (NW) lasers have manifested themselves as indispensable components in this field, associated with their extremely compact footprint and ultra-high optical gain within the 1D cavity. In this study, the carrier concentrations of indium phosphide (InP) NWs are actively controlled to modify their emissive properties at room temperature.
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Mechanical and Electrical Room, Quzhou Special Equipment Inspection & Testing Research Institute, Quzhou 324000, China.
Hypergraph neural networks have gained widespread attention due to their effectiveness in handling graph-structured data with complex relationships and multi-dimensional interactions. However, existing hypergraph neural network models mainly rely on planar message-passing mechanisms, which have limitations: (i) low efficiency in encoding long-distance information; (ii) underutilization of high-order neighborhood features, aggregating information only on the edges of the original graph. This paper proposes an innovative hierarchical hypergraph neural network (HCHG) to address these issues.
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