AI Article Synopsis
- Micelles can be created by combining coenzyme Q10 (CoQ10) with dipotassium glycyrrhizate (GZK2) using a γ-cyclodextrin (γ-CD) inclusion complex.
- The study found that as more GZK2 is added to CoQ10/γ-CD solution, the solubility of CoQ10 increases linearly until reaching a molar ratio of about 1.6, after which the concentration stabilizes.
- The results suggest that the process involves GZK2 displacing CoQ10 in the γ-CD cavity, leading to the development of CoQ10 micelles.
Article Abstract
Micelles can be formed from coenzyme Q10 (CoQ10) and dipotassium glycyrrhizate (GZK2) by using an inclusion complex of CoQ10 with γ-cyclodextrin (γ-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK2 to a supersaturated solution of the CoQ10/γ-CD inclusion complex led to a linear increase in the solubility of CoQ10 due to the formation of micelles of CoQ10 when the molar ratio of GZK2/γ-CD increased to ∼1.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (-) and the ratio of GZK2 to CoQ10 was 1. These results suggest that the formation of CoQ10 micelles with GZK2 might proceed via the displacement of CoQ10 by GZK2 in the γ-CD cavity followed by the formation of CoQ10 micelles.
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| http://dx.doi.org/10.1021/jp5065165 | DOI Listing |
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