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C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men. | LitMetric

C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men.

Muscle Nerve

College of Education and Human Performance, Institute of Exercise Physiology and Wellness, University of Central Florida, 12494 University Boulevard, Orlando, Florida, 32816, USA.

Published: January 2015

AI Article Synopsis

  • The study aimed to explore how serum C-terminal agrin fragment (CAF) levels relate to neuromuscular fatigue in older adults.
  • 22 healthy older adults participated, with blood samples taken to measure CAF and electromyographic tests used to gauge neuromuscular fatigue.
  • The results showed a significant negative correlation between CAF levels and fatigue in men, while no significant correlation was found in women, even after adjusting for age and body mass index.

Article Abstract

Introduction: The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults.

Methods: Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWCFT ) test.

Results: A significant inverse correlation for men was observed between CAF and PWCFT (r = -0.602; P = 0.05), but not for women (r = 0.208; P = 0.54). After controlling for age and body mass index, significant correlations (r = -0.69; P = 0.042) remained for men, but not for women (r = 0.12; P = 0.76).

Conclusions: These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.

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Source
http://dx.doi.org/10.1002/mus.24443DOI Listing

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