Histoplasma capsulatum var capsulatum is a dimorphic fungus endemic to the Ohio and Mississippi River Valleys of the United States. In this case report, a 33-year-old woman who presented with a right orbital mass causing progressive vision loss, diplopia, and facial swelling is described. Lateral orbitotomy with lateral orbital wall bone flap was performed for excisional biopsy of the lesion. The 1.5 × 1.8 × 2.3 cm cicatricial mass demonstrated a granulomatous lesion with necrosis and positive staining consistent with Histoplasma capsulatum var capsulatum infection. To the authors' knowledge, this is the first case of orbital histoplasmosis to be reported in the United States and the first case worldwide of orbital histoplasmosis due to Histoplasma capsulatum var capsulatum.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/IOP.0000000000000249 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Invasive fungal infections and oomycoses in cats 2. Antifungal therapy.
J Feline Med Surg
January 2024
Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, SAR China.
Article Synopsis
- Invasive fungal infections (IFIs) and fungal-like infections (IFLIs) are challenging to treat due to long treatment times, the potential for relapse, and variable antifungal drug effectiveness.
- The article aims to review the activity, mechanisms, and side effects of antifungal drugs, while discussing the treatment and prognosis for specific infections such as cryptococcosis and mucormycosis.
- Information is primarily based on pharmacokinetic studies in cats, along with data from preclinical and human studies, combining insights from various veterinary specialties.
Invasive Fungal Infections Complicating COVID-19: A Narrative Review.
J Fungi (Basel)
October 2021
Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy.
Invasive fungal infections (IFIs) can complicate the clinical course of COVID-19 and are associated with a significant increase in mortality, especially in critically ill patients admitted to an intensive care unit (ICU). This narrative review concerns 4099 cases of IFIs in 58,784 COVID-19 patients involved in 168 studies. COVID-19-associated invasive pulmonary aspergillosis (CAPA) is a diagnostic challenge because its non-specific clinical/imaging features and the fact that the proposed clinically diagnostic algorithms do not really apply to COVID-19 patients.
View Article and Find Full Text PDFHistoplasma Pyomyositis in a Patient with Disseminated Histoplasmosis and Anti-Synthetase Syndrome: Case-Based Review of Literature.
Mediterr J Rheumatol
September 2020
Background: Histoplasmosis is an endemic mycosis caused by Histoplasma Capsulatum, a thermally dimorphic fungus with mycelial and yeast forms. Muscle involvement is infrequent in Histoplasmosis.
Case: A 49-year-old lady presented with generalized myalgia and arthritis of two-year duration, which had responded partly to glucocorticoids.
Therapy of Non-Dermatophytic Mycoses in Animals.
J Fungi (Basel)
October 2018
Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.
This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed.
View Article and Find Full Text PDFPrimary cutaneous histoplasmosis mimicking basal cell carcinoma of the eyelid: A case report and review of literature.
Indian J Pathol Microbiol
January 2016
Department of Orbit, Oculoplasty and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute, Madurai, Tamil Nadu, India.
We present the case of a 46 years old gentleman with longstanding ulcerative lesion of the right upper eyelid. Biopsy of the lesion revealed intracellular periodic acid-Schiff positive round to oval organisms with a surrounding clear halo suggestive of histoplasmosis. Histoplasma capsulatum specific polymerase chain reaction was positive.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!