The aim of the present study was to investigate influences of threonine and tryptophan supplementation (TTS) on immune response of growing pigs inoculated with modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Twenty growing barrows (Landrace × Yorkshire) were randomly assigned to four groups according to the PRRS vaccination and TTS. Serum samples were collected from all pigs at days 0, 7, 14, 21, 28, 35, 49 post-vaccination (day 0 defined as the day of vaccination). Pigs were euthanized and samples collected at day 49 post-vaccination. The results showed that TTS tended to increase weight gain and average daily gain (ADG) of pigs (P < 0.1). PRRS vaccine enhanced serum PRRSV-specific antibody, serum virus neutralizing (SVN) antibody and interferon-γ, interleukin (IL)-10 and IL-1β concentrations (P < 0.05). The expression of TLR3 and TLR7 mRNA in lymph nodes were higher in TTS than in the control group after PRRS vaccine inoculation (P < 0.05). TTS diet mitigated lung damage which is induced by PRRS vaccination from microscopic evaluation. These results suggest that dietary TTS could improve growth performance of growing pigs, which may be ascribed to the improved immune response and mitigated lung damage.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/asj.12272 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gas-Phase Fluorescence Excitation Experiments on Cryogenically Cold Rhodamine B Cations Linked to Various Amino Acid Esters.
J Am Soc Mass Spectrom
January 2025
Department of Physics and Astronomy, Aarhus University, Aarhus 8000, Denmark.
Article Synopsis
- FRET (Förster resonance energy transfer) is a technique used in gas-phase structural biology to analyze the structures of biological molecules like peptides and proteins by using donor and acceptor dyes.
- The study investigates how different amino acid (AA) methyl esters connected to a rhodamine dye affect energy transfer, employing cryogenic ion fluorescence spectroscopy for analysis.
- Results reveal that the variation in spectral outputs stems from the conformations of the dye, which are influenced by the AA side chains, and specific angles between two aromatic components that impact energy transfer efficiency.
Arginine depletion-induced autophagy and metabolic dysregulation are involved in the disease severity of hand, foot, and mouth disease.
Virulence
December 2025
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Amino acid metabolism provides significant insight into the development and prevention of many viral diseases. Therefore, the present study aimed to compare the amino acid profiles of hand, foot, and mouth disease (HFMD) patients with those of healthy individuals and to further reveal the molecular mechanisms of HFMD severity. Using UPLC-MS/MS, we determined the plasma amino acid expression profiles of pediatric patients with HFMD (mild, = 42; severe, = 43) and healthy controls ( = 25).
View Article and Find Full Text PDFRoles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis.
NPJ Biofilms Microbiomes
December 2024
Molecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, P.R. China.
Lung diseases often coincide with imbalances in gut microbiota, but the role of gut microbiota in pulmonary fibrosis (PF) remains unclear. This study investigates the impact of gut microbiota and their metabolites on PF. Serum and lung tissues of normal, bleomycin (BLM)- and silica-induced mice showed significant differences in gut microbiota.
View Article and Find Full Text PDF[Metabolomics study on anti-radiation effect of Yiguan Decoction].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Traditional Chinese Medicine,Guangdong Pharmaceutical University Guangzhou 511436, China Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences Beijing 100850, China.
The gas chromatography-mass spectrometer(GC-MS) metabolomics method was used to investigate the anti-radiation effect of Yiguan Decoction water extract on mice and explore its related pathways and mechanisms of action. Healthy SPF male mice from Kunming were randomly assigned to six groups: blank group, model group, positive drug group, and high-dose, medium-dose, and low-dose groups of Yiguan Decoction, with ten mice in each group. Mice were prophylactically dosed for six days, and ~(60)Co γ ray with 5 Gy was used to establish a radiation mouse model.
View Article and Find Full Text PDFEffect of dapagliflozin on the serum metabolome in patients with type 2 diabetes mellitus.
J Diabetes Metab Disord
June 2025
Department of Internal Medicine, University of Ioannina, Stavrou Niarchou Avenue, Ioannina, 45500 Greece.
Objectives: SGLT-2 inhibitors have been shown to exert cardio- and renoprotective actions. We aimed to investigate the underlying mechanisms using H-NMR based metabolomics in patients with type-2 diabetes mellitus who received dapagliflozin.
Methods: 50 patients with type 2 diabetes mellitus, inadequately controlled on metformin monotherapy (HbA1c > 7%) received dapagliflozin for 3 months and 30 matched patients received insulin degludec for 3 months.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!