We have designed a dual-color fluorescent reporter that can track microRNA expression in vitro, which can be used for lineage tracing experiments. We have used this system to track miR-140 promoter activity in breast cancer cells and to follow the impact of estrogen signaling in cancer stem cell subpopulations.
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| http://dx.doi.org/10.1007/978-1-4939-1346-6_4 | DOI Listing |
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