The mucous retention cyst of the minor salivary glands represent a specific type of oral mucocele which is lined by epithelium. It is caused probably from partial or complete obstruction of a duct. It affects older patients (over 40 years of age) most commonly women and it is located in different sites than the ordinary mucocele. In this paper we studied the histologic and histochemical features of four cases. The lining epithelium varied from cuboidal to columnar or flattened. Among the cells of the lining epithelium oncocytes were observed.
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Alzheimers Dement
December 2024
The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Background: Approximately 6.7 million people in the US are diagnosed with an Alzheimer's disease (AD), with greater incidence in women and minorities. Approximately 11 million family members provide uncompensated care to their family members with dementia, with more than 60% reporting high or very high levels of stress, a condition associated with increased risk for AD.
View Article and Find Full Text PDFInt J Surg Pathol
January 2025
Department of Oral Diagnosis, Piracicaba School of Dentistry, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Adv Rheumatol
January 2025
Department of Ophthalmology, Otolaryngology, Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Background: Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) are adaptive mechanisms for conditions of high protein demand, marked by an accumulation of misfolded proteins in the endoplasmic reticulum (ER). Rheumatic autoimmune diseases (RAD) are known to be associated with chronic inflammation and an ERS state. However, the activation of UPR signaling pathways is not completely understood in Sjögren's disease (SD).
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
King Abdulaziz Medical Center, National Guard Health Affairs, Riyadh 21423, Saudi Arabia.
Salivary gland tumors (SGTs) are diverse lesions with varying morphological and clinical characteristics. Limited data exist on the distribution of SGTs in Saudi Arabia. We aimed to fill this gap by examining the distribution of SGTs across four tertiary hospitals in Riyadh.
View Article and Find Full Text PDFNat Commun
January 2025
Rheumatology Research Group, Department of Inflammation and Ageing, College of Medicine & Health, University of Birmingham, Birmingham, UK.
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial relationship remain unknown. Here we use combine single-cell RNA-sequencing, spatial transcriptomics and proteomics of minor salivary glands of patients with Sjogren's disease and Sicca Syndrome, with ex-vivo functional studies to construct a cellular and spatial map of key components involved in the formation and function of tertiary lymphoid structures.
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