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Extreme variability in succinylcholine dose for muscle relaxation in electroconvulsive therapy.
Australas Psychiatry
August 2018
Assistant Professor, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Objectives: To determine what dose of succinylcholine falls outside the range of 2 SD above or below the mean optimal dose of 0.9 mg/kg used for electroconvulsive therapy (ECT).
Methods: In this retrospective chart review, for all patients who received ECT at our institution within the 5-year study period, the initial dose of succinylcholine in milligrams per kilogram was compared with subsequent doses after adjustments were made for individual patient responses.
Single sea urchin phagocytes express messages of a single sequence from the diverse Sp185/333 gene family in response to bacterial challenge.
J Immunol
December 2014
Department of Biological Sciences, George Washington University, Washington, DC 20052
Immune systems in animals rely on fast and efficient responses to a wide variety of pathogens. The Sp185/333 gene family in the purple sea urchin, Strongylocentrotus purpuratus, consists of an estimated 50 (±10) members per genome that share a basic gene structure but show high sequence diversity, primarily due to the mosaic appearance of short blocks of sequence called elements. The genes show significantly elevated expression in three subpopulations of phagocytes responding to marine bacteria.
View Article and Find Full Text PDFDosing and effectiveness of ketamine anesthesia for electroconvulsive therapy (ECT): a case series.
Australas Psychiatry
October 2014
Professor, Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, NY, USA
Objective: To provide additional data about the clinical efficacy and dosing range for ketamine used as the induction agent in electroconvulsive therapy (ECT).
Method: We reviewed the clinical data in our academic hospital ECT service over the last four years for patients who had received ketamine as the sole, or adjunctive, anesthesia induction agent. We extracted clinical data about antidepressant response as well as absolute and weight-based dosing for ketamine.
Aggregation of sea urchin phagocytes is augmented in vitro by lipopolysaccharide.
PLoS One
November 2013
Department of Biological Sciences, George Washington University, Washington, DC, United States of America.
Development of protocols and media for culturing immune cells from marine invertebrates has not kept pace with advancements in mammalian immune cell culture, the latter having been driven by the need to understand the causes of and develop therapies for human and animal diseases. However, expansion of the aquaculture industry and the diseases that threaten these systems creates the need to develop cell and tissue culture methods for marine invertebrates. Such methods will enable us to better understand the causes of disease outbreaks and to develop means to avoid and remedy epidemics.
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