Background: Primary Hypertension (HT) is the most prevalent cardiovascular disorder worldwide and is accompanied by significant morbidity and mortality.
Objectives: The present study aimed to investigate the kinetics of orthostatic Blood Pressure (BP) in primary hypertensive patients during the change from supine position to standing position as well as during the standing position using the Orthostatic Test (OT).
Patients And Methods: This prospective study included a group of 107 primary hypertensive patients (mean age: 55.82 ± 11.35 years, ranging from 39 to 80 years). Orthostatic systolic BP (Ortho SBP) was recorded for 10 minutes at the rhythm of 3 measurements per minute and was compared to the values of supine systolic preorthostatic (Preortho SBP). According to the changes in Ortho SBP, three subgroups of primary hypertensive patients were selected as follows: Subgroup A: Ortho SBP was higher than mean Preortho SBP by 10 mmHg or more. Subgroup B: Ortho SBP was lower than mean Preortho SBP by 20 mmHg or more. Subgroup C: -20 mmHg < (Ortho SBP - Preortho SBP) < + 10 mmHg. The kinetics of each group was then recorded.
Results: In this study, the prevalence of subgroups A, B, and C was 27.1%, 15.9%, and 57.0%, respectively. In subgroup A, the adrenergic peripheral sympathetic alpha response was 20% during the OT.
Conclusions: Hypertensives with very similar supine SBP behavior could exhibit widely different Ortho SBP. Thus, careful and effective treatment of hypertensives requires careful consideration and assessment of orthostatic BP.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109041 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Rational mutagenesis of an epoxide hydrolase and its structural mechanism for the enantioselectivity improvement toward chiral ortho-fluorostyrene oxide.
Int J Biol Macromol
December 2024
School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, PR China. Electronic address:
Chiral (S)-o-fluorostyrene oxide (oFSO) and vicinal diol (R)-o-fluorophenylethane-1,2-diol (oFPED) are important intermediates for synthesizing treatments for neuropathic diseases. This study aimed to engineer Aspergillus usamii epoxide hydrolase (AuEH2) through a rational mutagenesis strategy to customize high enantioselectivity mutant for rac-oFSO. Out of 181 single-site mutants screened, six showed elevated enantiomeric ratio (E value) ranging from 32 to 108 according to E value and activity mutability landscapes.
View Article and Find Full Text PDFComparison of the Magnesium Sulphate With Paracetamol Combination vs the Fentanyl With Lignocaine Combination in Attenuating the Hemodynamic Response During Laryngoscopy and Intubation: A Prospective, Double-Blinded Randomized Controlled Study.
Cureus
August 2024
Anaesthesiology, Pondicherry Institute of Medical Sciences, Pondicherry, IND.
Background and aims Laryngoscopy and intubation cause an increased sympatho-adrenergic pressor response, which can be detrimental to patients with coronary artery disease, hypertension, etc. Various drugs and manoeuvres have been tried to reduce the pressor response with acceptable results but the quest for the ideal drug still continues. Hence, we planned to compare the effects of magnesium sulfate with paracetamol and fentanyl with lignocaine on attenuating the hemodynamic responses due to direct laryngoscopy and intubation and to note the complications of these drugs.
View Article and Find Full Text PDFOxidation-dependent Lewis acidity in chalcogen adducts of Sb/P frustrated Lewis pairs.
Dalton Trans
July 2024
Chair of Inorganic and Structural Chemistry, Center for Molecular Materials CM2, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, Bielefeld 33615, Germany.
The reactions of the frustrated Lewis pair (FC)SbCHP(Bu) with oxygen, sulphur, selenium and tellurium led to the mono-oxidation products (FC)SbCHP(E)(Bu) (E = O, S, Se, Te). Further oxidation of these chalcogen adducts with tetrachloro--benzoquinone (-chloranil) gave (FC)Sb(CH)(μ-E)P(Bu)·Cat (Cat = -OCCl) with a central four-membered ring heterocycle for E = O, S, and Se. For E = Te the elimination of elemental tellurium led to an oxidation product with two equivalents of -chloranil, (FC)SbCHP(Bu)·2Cat, which is also accessible by reaction of (FC)SbCHP(Bu) with -chloranil.
View Article and Find Full Text PDFQuantifying Hemodynamic Cardiac Stress and Cardiomyocyte Injury in Normotensive and Hypertensive Acute Heart Failure.
Biomedicines
May 2024
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland.
Article Synopsis
- * Among 1,152 patients studied, those with normotensive acute heart failure exhibited significantly higher levels of hemodynamic stress and heart cell injury markers compared to those who were hypertensive.
- * The findings indicated that normotensive patients had a higher risk of mortality, particularly if their biomarker levels were elevated, which was confirmed in a separate cohort of 324 patients.
Associations of Ambulatory Blood Pressure Measurements With High-Sensitivity Troponin and Natriuretic Peptide Levels in SPRINT.
Am J Hypertens
July 2024
Department of Medicine, Kidney Health Research Collaborative, San Francisco Veterans Affairs Health Care System and University of California San Francisco, San Francisco, California, USA.
Article Synopsis
- - Nighttime blood pressure (BP) is more closely linked to heart disease risk than daytime BP, yet its relationship with early heart disease indicators is not well understood.
- - A study involving 897 participants found that higher nighttime BP was significantly associated with increased levels of heart-related biomarkers, specifically NT-proBNP and hs-cTnT, indicating potential heart issues.
- - While both nighttime and daytime BP were linked to higher hs-cTnT levels, only nighttime BP showed a strong connection to NT-proBNP levels, suggesting it may be a more important factor in assessing cardiovascular health.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!