AI Article Synopsis
- The innate immune response, which involves cells like macrophages, neutrophils, and dendritic cells, is crucial for fighting off Mucorales fungi, with varying effectiveness against different species.
- Factors such as cytokines, growth factors, and specific antifungal agents can enhance the innate immune response to Mucorales.
- These insights point to potential new adjunctive therapies for treating patients suffering from invasive mucormycosis.
Article Abstract
Innate immune response, including macrophages, neutrophils and dendritic cells and their respective receptors, plays an important role in host defences against Mucorales with differential activity against specific fungal species, while adaptive immunity is not the first line of defence. A number of endogenous and exogenous factors, such as cytokines and growth factors as well as certain antifungal agents have been found that they influence innate immune response to these organisms. Used alone or especially in combination have been shown to exert antifungal effects against Mucorales species. These findings suggest novel ways of adjunctive therapy for patients with invasive mucormycosis.
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| http://dx.doi.org/10.1111/myc.12236 | DOI Listing |
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