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[CTIP2, a multifunctional protein: cellular physiopathology and therapeutic implications]. | LitMetric

[CTIP2, a multifunctional protein: cellular physiopathology and therapeutic implications].

Med Sci (Paris)

Institut de parasitologie et de pathologie tropicale, EA7292, université de Strasbourg, Strasbourg, France - IUT de Schiltigheim, 1 allée d'Athènes, Schiltigheim, France.

Published: November 2014

AI Article Synopsis

Article Abstract

The transcription factor CTIP2 (BCL11B) is a multifunctional protein involved in numerous cell physiological processes. To date, many molecular mechanisms underlying this process have been discovered, which highlighted the importance of the epigenetic regulation of genes and the regulation of the elongation factor P-TEFb. Furthermore studies of the deregulation of CTIP2 showed the association of CTIP2 to numerous pathologies including cancer and cardiac hypertrophy. A better comprehension of the physiopathology of these diseases might lead to the design of therapeutical strategies intending to prevent CTIP2 deregulation. Moreover, CTIP2 and its associated proteins constitute potential targets in strategies aiming to reduce and/or purge HIV-1 cell reservoirs.

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Source
http://dx.doi.org/10.1051/medsci/20143008019DOI Listing

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