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Sensory-evoked LTP driven by dendritic plateau potentials in vivo. | LitMetric

Sensory-evoked LTP driven by dendritic plateau potentials in vivo.

Nature

Department of Basic Neurosciences and the Center for Neuroscience, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland.

Published: November 2014

AI Article Synopsis

  • Long-term synaptic potentiation (LTP) is crucial for memory formation and synaptic network plasticity, traditionally linked to action potentials in neurons.
  • Research shows that, in the mouse somatosensory cortex, whisker stimulation can induce LTP in pyramidal cells without the need for action potentials, relying instead on long-lasting depolarizations involving NMDAR receptors.
  • The study demonstrates that sensory input activates synaptic networks from the thalamus, leading to these depolarizations and LTP, indicating a collaborative process between different pathways rather than just somatic action potentials.

Article Abstract

Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local dendritic depolarization has been shown to mediate these forms of LTP as well. As pyramidal cells in supragranular layers of the somatosensory cortex spike infrequently, it is unclear which of the two mechanisms prevails for those cells in vivo. Using whole-cell recordings in the mouse somatosensory cortex in vivo, we demonstrate that rhythmic sensory whisker stimulation efficiently induces synaptic LTP in layer 2/3 (L2/3) pyramidal cells in the absence of somatic spikes. The induction of LTP depended on the occurrence of NMDAR (N-methyl-d-aspartate receptor)-mediated long-lasting depolarizations, which bear similarities to dendritic plateau potentials. In addition, we show that whisker stimuli recruit synaptic networks that originate from the posteromedial complex of the thalamus (POm). Photostimulation of channelrhodopsin-2 expressing POm neurons generated NMDAR-mediated plateau potentials, whereas the inhibition of POm activity during rhythmic whisker stimulation suppressed the generation of those potentials and prevented whisker-evoked LTP. Taken together, our data provide evidence for sensory-driven synaptic LTP in vivo, in the absence of somatic spiking. Instead, LTP is mediated by plateau potentials that are generated through the cooperative activity of lemniscal and paralemniscal synaptic circuitry.

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Source
http://dx.doi.org/10.1038/nature13664DOI Listing

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