[Structure-activity relation for rhodomycin-type antibiotics and the inhibition kinetics of single-stranded and double-stranded DNA- and RNA-viruses].

The antiviral activity of anthracycline antibiotics of rhodomycin group was investigated by two independent methods which determined the infectious units or antigenicity of the viruses. The action of rhodomycin depended on the structure, number, and position of amino sugar in aglycon. The antiviral activity was found to increase in serial order: iremycin--adriamycin--daunomycin--alpha-rubicin--beta-rhodom ycin-- violamycin B I complex by inhibition kinetics determined with adenovirus.