Four alkaloids named hosieines A-D were isolated from the root and stem of Ormosia hosiei. Their flat structures were established by mass spectrometry and by a combination of NMR experiments. These molecules probably share a common biosynthetic origin with the lupin alkaloids but they differ in the formation of the last ring, being here part of a rare 2-azabicyclo[3.2.1]octane system. Their absolute configuration was determined by X-ray crystallography using CuKα radiation. As has been described for cytisine, they display a remarkable affinity towards neuronal nicotinic acetylcholine α4β2 receptor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2014.07.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Elevated CO concentration enhance carbon and nitrogen metabolism and biomass accumulation of Ormosiahosiei.
Plant Physiol Biochem
July 2024
College of Forestry, Guizhou University, Guiyang, China; Institute for Forest Resources and the Environment of Guizhou, Guizhou University, Guiyang, China. Electronic address:
Elevated CO concentrations may inhibit photosynthesis due to nitrogen deficiency, but legumes may be able to overcome this limitation and continue to grow. Our study confirms this conjecture well. First, we placed the two-year-old potted saplings of Ormosia hosiei (O.
View Article and Find Full Text PDFHosimosines A-E, structurally diverse cytisine derivatives from the seeds of Ormosia hosiei Hemsl. et Wils.
Fitoterapia
October 2023
Department of Pharmacy, College of Medicine, Jiaxing University, Jiaxing 314001, China. Electronic address:
Ormosia hosiei Hemsl. et Wils (Fabaceae family) is an arbor species endemic to China. The seeds of O.
View Article and Find Full Text PDFPhytochemical compositions and biological activities of the branches and leaves of Ormosia hosiei Hemsl. et Wils.
J Pharm Biomed Anal
March 2023
College of Pharmacy, Fujian Key laboratory of Chinese Materia Medica, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Fujian-Macao Science and Technology Cooperation Base of Traditional Chinese Medicine-Oriented Chronic Disease Prevention and Treatment, Innovation and Transformation Center, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China. Electronic address:
Ormosia hosiei Hemsl. et Wils. is an economical and medicinal plant, increasingly cultivated in China; however, its branches and leaves are often pruned as waste.
View Article and Find Full Text PDFMating Systems of Single Families and Population Genetic Diversity of Endangered in South China.
Genes (Basel)
November 2022
Zhejiang Provincial Key Laboratory of Tree Breeding, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Fuyang 311400, China.
is a tree species native to China that has been extensively used for ornamental and furniture purposes due to its valued timber. The mating system has substantial impact on genetic diversity and structure of plant natural population. Such information should be considered when planning tree planting for forest restoration.
View Article and Find Full Text PDFCytisine-like alkaloids from the seeds of Hemsl. et Wils.
Nat Prod Res
April 2023
College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.
Two new cytisine-like alkaloids, hositisines C () and D (), were isolated from the seeds of along with four known compounds, (-)-tinctorine (), -adenosine (), 2'-deoxyadenosine (), and 7, 2', 4'-trihydroxy-5-methoxyisoflavanone (). Their structures were established using extensive spectroscopic techniques (UV, IR, CD, HRESIMS, 1 D and 2 D NMR). In the cytotoxic activity, compounds - and 5-fluorouracil (positive control) displayed inhibitory effects against HepG2 cells, exhibiting IC values of 44.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!