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Long-term therapeutic effects of allogeneic mesenchymal stem cell transplantation for intrauterine adhesions.
Stem Cell Res Ther
December 2024
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Background: Intrauterine adhesion (IUA), resulting from uterine trauma, is one of the major causes of female infertility. Previous studies have demonstrated that endometrial mesenchymal stem cells (eMSC) have therapeutic effects on IUA through cellular secretions. It is particularly true for most of the pre-clinical experiments performed on multiple animal models, as human-derived eMSC cannot maintain long-term engraftment in animals.
View Article and Find Full Text PDFClinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation.
Semin Immunopathol
December 2024
Division of Pediatric Stem Cell Transplantation and Immunology, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Toleration of a semi-allogeneic fetus in the mother's uterus as well as tolerance after allogeneic hematopoietic stem cell transplantation (HSCT) appear to share some immunologic concepts. The existence of microchimeric cells, and the original idea of a bidirectional cell trafficking between mother and child during pregnancy have been known for decades. Today, origins and mechanisms of persistence of microchimeric cells are intensively being elucidated.
View Article and Find Full Text PDFEndometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification.
Cell Mol Biol Lett
October 2024
Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Article Synopsis
- Acute transplant rejection is a major challenge in organ transplantation, and this study investigates the potential of endometrial regenerative cell-derived exosomes (ERC-Exos) to mitigate this issue by targeting a specific immune-regulating molecule, SLAMF6.
- The experimental results showed that treatment with ERC-Exos containing siSLAMF6 led to longer survival of transplanted organs in mice, altered cytokine profiles in the serum, and reduced the activation of harmful T cells.
- This research suggests that ERC-Exos can effectively modify immune responses by promoting the differentiation of regulatory T cells while inhibiting the proliferation of Th1 and Th17 cells, which are associated with transplant rejection.
Pregnancy-related factors induce immune tolerance through regulation of sCD83 release.
Front Immunol
September 2024
Research Laboratory, Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
A well-balanced maternal immune system is crucial to maintain fetal tolerance in case of infections during pregnancy. Immune adaptations include an increased secretion of soluble mediators to protect the semi-allogeneic fetus from excessive pro-inflammatory response. B lymphocytes acquire a higher capacity to express CD83 and secrete soluble CD83 (sCD83) upon exposure to bacteria-derived components such as LPS.
View Article and Find Full Text PDFThe Effect of Seminal Plasma on the Equine Endometrial Transcriptome.
Reprod Domest Anim
September 2024
Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA.
The establishment of pregnancy involves a fine-tuned balance between protection and tolerance within the maternal immune system, as the female needs to accept a foreign antigen (the semi-allogenic fetus) while still being able to combat pathogens from the uterus. In the horse, the first uterine exposure to paternal antigens is during mating when sperm is introduced to the tissue and draining lymphatics of the uterus. Additionally, it has been suggested that seminal plasma and its proteins within it play an essential role in preparing the female tract for a suitable immunologic environment but this has not been confirmed in the horse.
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