In this issue of , Kiel et al identify novel and high-frequency gain-of-function mutations involving genes of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway in T-cell prolymphocytic leukemia (T-PLL), paving the way for new targeted therapies.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148755PMC
http://dx.doi.org/10.1182/blood-2014-06-576942DOI Listing

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