Solar ultraviolet (UV) radiation is a major cause of erythema and skin cancer in humans and the face is one of the highest risk sites. Biologically effective UV irradiation (UVBE) is wavelength-dependent, and risk assessment has been demonstrated based on the value of the received UV radiation. Therefore, this study measured the face skin exposure to UV spectral irradiance using a spectroradiometer and a head manikin, which were weighted by action spectra to calculate the UVBE that causes erythema (UVBEery), non-melanoma (UVBEnon-mel), human squamous cell cancer (UVBEh-SCC), and DNA damage (UVBEDNA-d). We determined that the biologically effective UVB and UVA irradiances on clear sky days had peak values at 65-73° SEA (8-9 UVI) and 55-68° SEA (6-7 UVI), respectively. In the 10-30° SEA range, the highly skin-damaging wavelengths were all observed at 300 nm. However, in the 30-60°, 60-81°, and 10-81° SEA ranges, the highly skin damaging wavelengths were 300 nm, 304 nm and 300 nm for UVBEery, respectively; 304 nm, 306 nm and 304 nm for UVBEnon-mel, respectively; all 305 nm for UVBEh-SCC, and two small peaks at 302 nm and 312 nm for UVBEDNA-d.
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http://dx.doi.org/10.1016/j.jphotobiol.2014.08.004 | DOI Listing |
Hepatology
January 2025
Université Côte d'Azur, INSERM, U1065, C3M, Nice, France.
Background And Aims: Alcohol-related liver disease (ALD) is one of the leading causes of severe liver disease with limited pharmacological treatments for alcohol-related steatohepatitis (ASH). CD44, a glycoprotein mainly expressed in immune cells, has been implicated in multiple inflammatory diseases but has never been studied in the ALD context. We therefore studied its contribution to ASH development in mice and its expression in ALD patients.
View Article and Find Full Text PDFJ Strength Cond Res
December 2024
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Rome Open University, Rome, Italy; and.
Racil, G, Padulo, J, Trabelsi, Y, Frizziero, A, Russo, L, and Migliaccio, GM. Rhythmic exercises before basketball training: A study on motor skills, static balance, and reaction speed in school-aged children. J Strength Cond Res 38(12): e761-e768, 2024-The aim of this study was to investigate the effects of combining rhythmic exercises with basketball training on the improvement of basic motor and physical skills in children.
View Article and Find Full Text PDFBioconjug Chem
January 2025
Department of Biochemistry, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, ul. Lwowska 1, 87-100 Torun, Poland.
l-Asparaginase (l-ASNase) catalyzes the hydrolysis of l-asparagine, leading to its depletion and subsequent effects on the cellular proliferation and survival. In contrast to normal cells, malignant cells that lack asparagine synthase are extremely susceptible to asparagine deficiency. l-ASNase has been successfully employed in treating pediatric leukemias and non-Hodgkin lymphomas; however, its usage in adult patients and other types of cancer is limited due to significant side effects and drug resistance.
View Article and Find Full Text PDFJ Med Chem
January 2025
Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Pharmaceutical Sciences, Central University of Punjab, Bathinda 151 401, India.
The multifactorial nature of cancer requires treatment that involves simultaneous targeting of associated overexpressed proteins and cell signaling pathways, possibly leading to synergistic effects. Herein, we present a systematic study that involves the simultaneous inhibition of human topoisomerases (hTopos) and histone deacetylases (HDACs) by multitargeted quinoline-bridged hydroxamic acid derivatives. These compounds were rationally designed considering pharmacophoric features and catalytic sites of the cross-talk proteins, synthesized, and assessed for their anticancer potential.
View Article and Find Full Text PDFCBE Life Sci Educ
March 2025
Department of Genetics, University of Georgia, Athens, GA 30602.
Teaching evaluation at many institutions is insufficient to support, recognize, and reward effective teaching. We developed a long-term intervention to support science, technology, engineering, and mathematics (STEM) department heads in advancing teaching evaluation practices. We describe the intervention and systematically investigate its impact on departmental practices within a research-intensive university.
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