Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Circadian blood pressure (BP) patterns are regulated mainly by autonomic nerve system. Ambulatory blood pressure monitoring (ABPM) reveals that BP has circadian pattern over a 24 h period. The decline in nocturnal BP by 10-20% is considered to be normal (a dipper pattern). Non-dipper, riser, and extreme-dipper circadian patterns are considered to be abnormal because of their association with poor prognosis and end organ damage such as heart failure and cerebral vascular disease (CVD). On the other hand, end organ damage alters circadian BP patterns especially at night and people with CVD or heart failure have a high prevalence of abnormal circadian BP patterns.
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