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Validation of Machine Learning-assisted Screening of PKC Ligands: PKC Binding Affinity and Activation.
Biosci Biotechnol Biochem
January 2025
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan.
Protein kinase C (PKC) is a family of serine/threonine kinases, and PKC ligands have the potential to be therapeutic seeds for cancer, Alzheimer's disease, and human immunodeficiency virus infection. However, in addition to desired therapeutic effects, most PKC ligands also exhibit undesirable pro-inflammatory effects. The discovery of new scaffolds for PKC ligands is important for developing less inflammatory PKC ligands, such as bryostatins.
View Article and Find Full Text PDFClinical evaluation of droplet digital PCR in suspected invasive pulmonary aspergillosis.
Clin Chim Acta
January 2025
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address:
Invasive pulmonary aspergillosis (IPA), the most common fungal infection, is associated with high mortality of affected patients. Traditional diagnostic methods exhibit limited sensitivity and specificity, raising big challenges for precise management of the patients. There is thus an urgent need to find out a timely and accurate diagnostic method in clinical practice.
View Article and Find Full Text PDFEvaluation of a smartphone-based markerless system to measure lower-limb kinematics in patients with knee osteoarthritis.
J Biomech
January 2025
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University Chengdu Sichuan Province China. Electronic address:
OpenCap, a smartphone-based markerless system, offers a cost-effective alternative to traditional marker-based systems for gait analysis. However, its kinematic measurement accuracy must be evaluated before widespread use in clinical practice. This study aimed to evaluate OpenCap for lower-limb joint angle measurements during walking in patients with knee osteoarthritis (OA) and to compare error metrics between patients and healthy controls.
View Article and Find Full Text PDFTiming of adverse childhood experiences and depressive, anxiety, comorbid symptoms among Chinese female nurses: A life course perspective.
Child Abuse Negl
January 2025
Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, Hangzhou China. Electronic address:
Background: Nurses demonstrate a greater vulnerability to developing depressive and anxiety symptoms compared to the general population. Adverse Childhood Experiences (ACEs) are known risk factors for mental health issues, but impact of timing of these experiences remains unclear.
Objective: To investigate associations between timing of ACEs and depressive, anxiety, comorbid symptoms.
The Chinese version of the patients' experiences scale for older inpatients in the medical group: Instrument development and cross-sectional validation study.
Geriatr Nurs
January 2025
West China Biomedical Big Data Center, West China Hospital of Sichuan University, Chengdu, China. Electronic address:
Value-based healthcare is increasingly emphasizing attention to patients' self-reported experiences. However, due to the lack of effective tools, older patients in China lack feedback on the comprehensive care experience. Based on the psychometric assessment procedure, we developed a new geriatric inpatient experience scale (GIES).
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