We study scalar mixing in heterogeneous conductivity fields, whose structural disorder varies from weak to strong. A range of stretching regimes is observed, depending on the level of structural heterogeneity, measured by the log-conductivity field variance. We propose a unified framework to quantify the overall concentration distribution predicting its shape and rate of deformation as it progresses toward uniformity in the medium. The scalar mixture is represented by a set of stretched lamellae whose rate of diffusive smoothing is locally enhanced by kinematic stretching. Overlap between the lamellae is enforced by confinement of the scalar line support within the dispersion area. Based on these elementary processes, we derive analytical expressions for the concentration distribution, resulting from the interplay between stretching, diffusion, and random overlaps, holding for all field heterogeneities, residence times, and Péclet numbers.
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http://dx.doi.org/10.1103/PhysRevLett.110.204501 | DOI Listing |
Electromagn Biol Med
January 2025
Department of Applied Mathematics, University of Calcutta, Kolkata, India.
The current investigation explores tri-hybrid mediated blood flow through a ciliary annular model, designed to emulate an endoscopic environment. The human circulatory system, driven by the metachronal ciliary waves, is examined in this study to understand how ternary nanoparticles influence wave-like flow dynamics in the presence of interfacial nanolayers. We also analyze the effect of an induced magnetic field on Ag-Cu-/blood flow within the annulus, focusing on thermal radiation, heat sources, buoyancy forces and ciliary motion.
View Article and Find Full Text PDFAppl Biochem Biotechnol
January 2025
Centre for Applied Research, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, Tamil Nadu, 602105, India.
Nelumbo nucifera, an aquatic crop cultivated throughout Asian countries, belongs to the Nelumbonaceae family and has been widely used in traditional medicines with key pharmacological activities such as anti-viral, antipyretic, antioxidant, anti-steroid, anti-inflammatory, anti-arrhythmia, anti-obesity, and anti-aging properties. The present study aims to explore and assess the phytochemical composition, GC-MS profiling, antioxidant efficacy, and the major phytoconstituent phytol subjected to theoretical spectroscopic characterization using the DFT method. The phytochemical profiling of N.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Institute for Bioanalysis, University of Applied Sciences Coburg, Coburg, Germany.
Biocides, applied in building materials as antimicrobial protectants, can be leached out by rain, presenting substantial environmental risks as confirmed by studies on aquatic environments. However, these biocides are consistently released throughout the year in a diluted form, posing unique challenges for the prediction of transport, transformation, and ecotoxicity assessment in soil. To address this challenge, we combined COMLEAM, which predicts leaching from facades into the soil, with the FOCUS PELMO pesticide model to predict biocide distribution in soil.
View Article and Find Full Text PDFBackground: Intrathecally (IT) delivered antisense oligonucleotides (ASOs) are promising therapies that can reduce tau pathology in Alzheimer's Disease (AD). However, current plasma and CSF sampling methods to estimate brain tissue exposure of ASOs are inherently limited, hampering ASO clinical developmental plans. We developed the PET tracer [F]BIO-687, which binds ASO conjugates (ASO-Tz) in vivo, allowing us to image ASO distribution in a living brain using "pretargeted" imaging.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Background: We examined whether brain amyloid PET, hippocampal volume, or plasma biomarkers are better predictors of conversion to mild cognitive impairment (MCI).
Method: In the Baltimore Longitudinal Study of Aging (BLSA), plasma Aβ, Aβ, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) concentrations were measured using Quanterix Simoa Neurology 4-plex E. Plasma p-tau181 and p-tau231 concentrations were measured using in-house Simoa assays at University of Gothenburg.
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