The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C-H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142839 | PMC |
| http://dx.doi.org/10.3762/bjoc.10.161 | DOI Listing |
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