In the asymmetric unit of the title compound, C17H12F3NO4S, there are two conformationally similar mol-ecules in which the heterocyclic thia-zine ring adopts a half-chair conformation, with the dihedral angle between the two benzene rings being 24.84 (8) and 37.42 (8)°. In the crystal, the mol-ecules form dimers through cyclic carb-oxy-lic acid O-H⋯O hydrogen-bonding associations [graph set R (2) 2(8)] and are extended into chains along [101] through weak C-H⋯Osulfin-yl hydrogen bonds [graph set R (2) 2(14)]..
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120568 | PMC |
http://dx.doi.org/10.1107/S1600536814013245 | DOI Listing |
Life Sci Alliance
April 2025
https://ror.org/0220qvk04 Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
A pangenome is the sum of the genetic information of all individuals in a species or a population. Genomics research has been gradually shifted to a paradigm using a pangenome as the reference. However, in disease genomics study, pangenome-based analysis is still in its infancy.
View Article and Find Full Text PDFData Min Knowl Discov
January 2025
CWI, Amsterdam, The Netherlands.
Missing values arise routinely in real-world sequential (string) datasets due to: (1) imprecise data measurements; (2) flexible sequence modeling, such as binding profiles of molecular sequences; or (3) the existence of confidential information in a dataset which has been deleted deliberately for privacy protection. In order to analyze such datasets, it is often important to replace each missing value, with one or more letters, in an efficient and effective way. Here we formalize this task as a combinatorial optimization problem: the set of constraints includes the of the missing value (i.
View Article and Find Full Text PDFWe introduce a computational topology-based approach with unsupervised machine-learning algorithms to estimate the database size and content of RNA-like graph topologies. Specifically, we apply graph theory enumeration to generate all 110,667 possible 2D dual graphs for vertex numbers ranging from 2 to 9. Among them, only 0.
View Article and Find Full Text PDFMultiplexed Immunofluorescence (MxIF) enables detailed immune cell phenotyping, providing critical insights into cell behavior within the tumor immune microenvironment (TIME). However, signal integrity can be compromised due to the complex cyclic staining processes inherent to MxIF. Hematoxylin and Eosin (H&E) staining, on the other hand, offers complementary information through its depiction of cell morphology and texture patterns and is often visually cross-referenced with MxIF in clinical settings.
View Article and Find Full Text PDFJ Biomed Inform
January 2025
Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, 02115, MA, USA; VA Boston Healthcare System, 150 S Huntington Ave, Boston, 02130, MA, USA. Electronic address:
Objective: Electronic health record (EHR) systems contain a wealth of clinical data stored as both codified data and free-text narrative notes (NLP). The complexity of EHR presents challenges in feature representation, information extraction, and uncertainty quantification. To address these challenges, we proposed an efficient Aggregated naRrative Codified Health (ARCH) records analysis to generate a large-scale knowledge graph (KG) for a comprehensive set of EHR codified and narrative features.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!