AI Article Synopsis
- TLRs are special receptors in our immune system that help control diseases like multiple sclerosis (MS).
- Scientists want to create medicines that can help MS by changing how TLRs work, but many tests for these medicines haven’t been successful.
- The text talks about how TLRs can be used to create better and safer treatments for MS and other related diseases.
Article Abstract
Evolving data have shown that the toll like receptors (TLRs) family of innate immune receptors has an important role in driving the activation and inhibition of pathogenic pathways involved in multiple sclerosis (MS). While developing clinical trials targeting MS by TLRs modulators are of considerable interest, several of them have failed. Herein, the various consequences of TLRs pathways activation and the potential of targeting these receptors for therapeutic purposes are described. In particular, different aspects of TLR based therapies are discussed, in order to develop more efficacious and safe therapies targeting inflammatory and autoimmune diseases, especially MS.
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| http://dx.doi.org/10.1586/1744666X.2014.953061 | DOI Listing |
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