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Thiamine deficiency in infancy: long-term follow-up. | LitMetric

Thiamine deficiency in infancy: long-term follow-up.

Pediatr Neurol

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Published: September 2014

AI Article Synopsis

Article Abstract

Background: In 2003, several hundred Israeli infants risked thiamine deficiency after being fed a soy-based formula deficient in thiamine. Approximately 20 patients were seriously affected, and three of them died. We report the clinical presentation of acute encephalopathy in 11 children and the long-term sequelae of eight children who initially survived.

Patients: In the acute phase, six had bulbar signs, five had ophthalmologic signs and two had phrenic neuropathy. Three of the five patients with cardiac involvement had cardiomyopathy and died in the acute phase. One patient presented with a complete atrioventricular block.

Results: In the long-term, one patient, who was in a chronic vegetative state, died after 6 years. Seven children exhibited mental retardation and motor abnormalities, six developed severe epilepsy, two early kyphoscoliosis, and one patient remained with a complete atrioventricular block.

Conclusions: Infants who survive severe infantile thiamine deficiency have serious residual motor and cognitive sequelae as well as epilepsy.

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Source
http://dx.doi.org/10.1016/j.pediatrneurol.2014.05.010DOI Listing

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