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Letter to Editor from McCarroll et al: "Approach to the Patient: Normocalcemic Primary Hyperparathyroidism".
J Clin Endocrinol Metab
December 2024
Mater Misericordiae University Hospital, Dublin, Ireland.
Bone Mineral Density and First Line Imaging with [F]fluorocholine PET/CT in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism: Results from a Single Center.
Diagnostics (Basel)
November 2024
Department of Nuclear Medicine and Endocrinology, University Hospital Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria.
: Primary hyperparathyroidism (PHPT) is associated with normal or elevated calcium levels and affects bone mineral density. The proportion of cases predisposed to metabolic bone disease is unknown in patients with PHPT. The aim of this study was to assess bone mineral density and bone quality in patients with normo- or hypercalcemic primary hyperparathyroidism undergoing baseline parathyroid gland assessment with [F]fluorocholine PET/CT imaging.
View Article and Find Full Text PDFInfluence of normocalcemic primary hyperparathyroidism in bone density alterations of the jaws in patients with periodontitis.
Med Oral Patol Oral Cir Bucal
January 2025
University of Valencia, c/Gascó Oliag nº1 Valencia, ZIP:46010, Spain
Article Synopsis
- Normocalcemic Primary Hyperparathyroidism (NPHPT) leads to excess secretion of parathyroid hormone (PTH), increasing bone resorption and potentially affecting periodontal health due to shared pathological mechanisms.* -
- A study involving 86 NPHPT patients and 87 controls evaluated bone density and periodontal status, revealing that NPHPT patients had a higher incidence of severe periodontitis compared to the control group.* -
- The findings suggested a significant relationship between NPHPT and periodontitis, with NPHPT patients having 1.78 times greater odds of developing periodontitis, linked to increased PTH levels and decreased vitamin D affecting bone density.*
Persistent elevated serum parathyroid hormone levels with normocalcaemia after parathyroidectomy: Secondary hyperparathyroidism or pseudo- hyperparathyroidism?
Cir Esp (Engl Ed)
November 2024
Servicio Cirugía General y Digestiva, Hospital Universitario de Gran Canaria Dr. Negrín, Spain.
Article Synopsis
- The study examined how long it takes for parathyroid hormone (PTH) levels to return to normal after parathyroid surgery for primary hyperparathyroidism, evaluating data from 186 patients over five years.
- Out of the final group of 176 patients, 26.1% had elevated PTH levels post-surgery despite normal calcium levels, with a median time to normalization of 6 months.
- Findings suggest that high preoperative PTH levels can predict postoperative normocalcaemic hyperparathyroidism, while vitamin D and creatinine levels don’t appear to impact the normalization timeline.
Persistent elevation of parathyroid hormone after curative parathyroidectomy: A risk factor for recurrent hyperparathyroidism.
World J Surg
January 2025
Department of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Background: Up to 45% of patients may have persistently elevated parathyroid hormone (PTH) levels after curative parathyroidectomy for primary hyperparathyroidism (PHPT), although the clinical significance is unclear. We aimed to assess the long-term clinical significance of persistently elevated PTH early after parathyroidectomy.
Methods: A prospectively collected institutional database was queried for patients who underwent parathyroidectomy for sporadic PHPT between 12/99 and 6/22 and had normal serum calcium levels at 6 months postoperatively.
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