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Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles.
J Nanobiotechnology
January 2025
Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Background: Both oxidative stress and autoimmune responses play crucial roles in the development of vitiligo. Under oxidative stress, the apoptotic melanocytes expose self-antigens and release high mobility group box 1 (HMGB1), triggering autoimmune activation and recruiting CD8 T cells. This process further leads to the destruction of melanocytes, resulting in the lack of melanin granules.
View Article and Find Full Text PDFAcceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive-compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-19 pandemic in a psychiatric outpatient department in Germany.
BMC Psychiatry
January 2025
Department of Psychiatry and Psychotherapy, Medical Faculty, Leipzig University, Leipzig, Germany.
Background: Cognitive behavior therapy (CBT) is the gold-standard treatment for obsessive-compulsive disorder (OCD). However, access to CBT and specialized treatments is often limited. This pilot study describes the implementation of a guided Internet-Based CBT program (ICBT) for individuals seeking treatment for OCD in a psychiatric outpatient department in Leipzig, Germany, during the COVID-19 pandemic.
View Article and Find Full Text PDFTooth vitality and periapical healing: is Biodentine at par with MTA in regenerative endodontics?
Evid Based Dent
January 2025
All India Institute of Medical Sciences, Bathinda, Punjab, India.
Design: The study is a prospective, double-blinded randomised control trial that compares the mineral trioxide aggregate (MTA) and Biodentine as the pulp space barrier material after induction of a periapical blood clot by over-instrumentation for endodontic regeneration in single-rooted mature permanent anterior tooth (closed apex) with apical periodontitis (periapical pathology of more than 3 mm) and having necrosed pulp. A total of 36 patients were included in the study and after randomisation were allocated equally to both the groups out of which 31 patients returned for follow-up over an 18-month period. The treatment protocol consisted of two separate appointments.
View Article and Find Full Text PDFAssociation between periodontitis and physical fitness in law enforcement workers.
Clin Oral Investig
January 2025
Unit of Periodontology, University College London, Eastman Dental Institute, London, UK.
Objectives: Oral and periodontal health have been linked to systemic health, cardiovascular disease and inflammation markers. Physical fitness has been linked to increased inflammatory response, but only few studies have investigated the association between oral health with physical activity. The aim of this study was to evaluate the association between oral and periodontal health status and physical fitness in British law enforcement workers.
View Article and Find Full Text PDFRole of inflammasomes in acute respiratory distress syndrome.
Thorax
January 2025
Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, UK.
Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its first description, no efficacious pharmacological therapies have been developed, and little progress has been made in improving clinical outcomes. Neutrophils are the principal drivers of ARDS, with their priming and subsequent aberrant downstream functions, including interleukin (IL) 1β and IL-18 secretion, central to the disease pathogenesis.
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